CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sal-like protein 1 
Protein Synonyms/Alias
 Spalt-like transcription factor 1; Zinc finger protein 794; Zinc finger protein SALL1; Zinc finger protein Spalt-1; HSal1; Sal-1 
Gene Name
 SALL1 
Gene Synonyms/Alias
 SAL1; ZNF794 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1086NSLSSLIKTEVNGFVsumoylation[1]
Reference
 [1] Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1.
 Netzer C, Bohlander SK, Rieger L, Müller S, Kohlhase J.
 Biochem Biophys Res Commun. 2002 Aug 30;296(4):870-6. [PMID: 12200128] 
Functional Description
 Transcriptional repressor involved in organogenesis (By similarity). 
Sequence Annotation
 ZN_FING 449 471 C2H2-type 1.
 ZN_FING 477 499 C2H2-type 2.
 ZN_FING 706 728 C2H2-type 3.
 ZN_FING 734 756 C2H2-type 4.
 ZN_FING 766 788 C2H2-type 5.
 ZN_FING 1001 1023 C2H2-type 6.
 ZN_FING 1029 1051 C2H2-type 7.
 ZN_FING 1134 1156 C2H2-type 8.
 ZN_FING 1162 1184 C2H2-type 9.
 MOD_RES 586 586 Phosphoserine (By similarity).
 MOD_RES 593 593 Phosphoserine.
 MOD_RES 595 595 Phosphoserine.
 MOD_RES 941 941 Phosphoserine.
 MOD_RES 943 943 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1324 AA 
Protein Sequence
MSRRKQAKPQ HFQSDPEVAS LPRRDGDTEK GQPSRPTKSK DAHVCGRCCA EFFELSDLLL 60
HKKNCTKNQL VLIVNENPAS PPETFSPSPP PDNPDEQMND TVNKTDQVDC SDLSEHNGLD 120
REESMEVEAP VANKSGSGTS SGSHSSTAPS SSSSSSSSSG GGGSSSTGTS AITTSLPQLG 180
DLTTLGNFSV INSNVIIENL QSTKVAVAQF SQEARCGGAS GGKLAVPALM EQLLALQQQQ 240
IHQLQLIEQI RHQILLLASQ NADLPTSSSP SQGTLRTSAN PLSTLSSHLS QQLAAAAGLA 300
QSLASQSASI SGVKQLPPIQ LPQSSSGNTI IPSNSGSSPN MNILAAAVTT PSSEKVASSA 360
GASHVSNPAV SSSSSPAFAI SSLLSPASNP LLPQQASANS VFPSPLPNIG TTAEDLNSLS 420
ALAQQRKSKP PNVTAFEAKS TSDEAFFKHK CRFCAKVFGS DSALQIHLRS HTGERPFKCN 480
ICGNRFSTKG NLKVHFQRHK EKYPHIQMNP YPVPEHLDNI PTSTGIPYGM SIPPEKPVTS 540
WLDTKPVLPT LTTSVGLPLP PTLPSLIPFI KTEEPAPIPI SHSATSPPGS VKSDSGGPES 600
ATRNLGGLPE EAEGSTLPPS GGKSEESGMV TNSVPTASSS VLSSPAADCG PAGSATTFTN 660
PLLPLMSEQF KAKFPFGGLL DSAQASETSK LQQLVENIDK KATDPNECII CHRVLSCQSA 720
LKMHYRTHTG ERPFKCKICG RAFTTKGNLK THYSVHRAMP PLRVQHSCPI CQKKFTNAVV 780
LQQHIRMHMG GQIPNTPVPD SYSESMESDT GSFDEKNFDD LDNFSDENME DCPEGSIPDT 840
PKSADASQDS LSSSPLPLEM SSIAALENQM KMINAGLAEQ LQASLKSVEN GSIEGDVLTN 900
DSSSVGGDME SQSAGSPAIS ESTSSMQALS PSNSTQEFHK SPSIEEKPQR AVPSEFANGL 960
SPTPVNGGAL DLTSSHAEKI IKEDSLGILF PFRDRGKFKN TACDICGKTF ACQSALDIHY 1020
RSHTKERPFI CTVCNRGFST KGNLKQHMLT HQMRDLPSQL FEPSSNLGPN QNSAVIPANS 1080
LSSLIKTEVN GFVHVSPQDS KDTPTSHVPS GPLSSSATSP VLLPALPRRT PKQHYCNTCG 1140
KTFSSSSALQ IHERTHTGEK PFACTICGRA FTTKGNLKVH MGTHMWNSTP ARRGRRLSVD 1200
GPMTFLGGNP VKFPEMFQKD LAARSGSGDP SSFWNQYAAA LSNGLAMKAN EISVIQNGGI 1260
PPIPGSLGSG NSSPVSGLTG NLERLQNSEP NAPLAGLEKM ASSENGTNFR FTRFVEDSKE 1320
IVTS 1324 
Gene Ontology
 GO:0010369; C:chromocenter; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0000792; C:heterochromatin; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0016581; C:NuRD complex; IEA:Compara.
 GO:0008013; F:beta-catenin binding; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IEP:UniProtKB.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; ISS:UniProtKB.
 GO:0048566; P:embryonic digestive tract development; IMP:UniProtKB.
 GO:0042733; P:embryonic digit morphogenesis; IMP:UniProtKB.
 GO:0035136; P:forelimb morphogenesis; IEA:Compara.
 GO:0008406; P:gonad development; IEP:UniProtKB.
 GO:0035137; P:hindlimb morphogenesis; IEA:Compara.
 GO:0016575; P:histone deacetylation; ISS:GOC.
 GO:0031129; P:inductive cell-cell signaling; ISS:UniProtKB.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEP:UniProtKB.
 GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0021889; P:olfactory bulb interneuron differentiation; ISS:UniProtKB.
 GO:0061034; P:olfactory bulb mitral cell layer development; IMP:UniProtKB.
 GO:0021553; P:olfactory nerve development; ISS:UniProtKB.
 GO:0042473; P:outer ear morphogenesis; IMP:UniProtKB.
 GO:0021983; P:pituitary gland development; IEP:UniProtKB.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:2000177; P:regulation of neural precursor cell proliferation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0072092; P:ureteric bud invasion; ISS:UniProtKB.
 GO:0003281; P:ventricular septum development; ISS:UniProtKB. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS