CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Signal transducer and transcription activator 6 
Protein Synonyms/Alias
  
Gene Name
 Stat6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
94IYQRDPLKLVATIRQubiquitination[1]
277TSSFLVEKQPPQVLKubiquitination[1]
595NIQPFSAKDLSIRSLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signaling. 
Sequence Annotation
 DOMAIN 517 632 SH2.
 MOTIF 793 797 LXXLL motif.
 MOD_RES 641 641 Phosphotyrosine; by JAK (By similarity).  
Keyword
 Activator; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; SH2 domain; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 837 AA 
Protein Sequence
MSLWGLISKM SPEKLQRLYV DFPQRLRHLL ADWLESQPWE FLVGSDAFCY NMASALLSAT 60
VQRLQATAGE QGKGNSILPH ISTLESIYQR DPLKLVATIR QILQGEKKAV IEEFRHLPGP 120
FHRKQEELKF TTALGRLQHR VRETRLLRES LQQGAKTGQV SLQNLIDPPV NGPGPSEDLA 180
TMLQGTVGDL EATQALVLKR IQIWKRQQQL AGNGTPFEES LAGLQERCES LVEIYSQLQQ 240
EIGAASGELE PKTRASLISR LDEVLRTLVT SSFLVEKQPP QVLKTQTKFQ AGVRFLLGLQ 300
FLGTSAKPPM VRADMVTEKQ ARELSLAQGP GTGVESTGEI MNNTVPLENS IPSNCCSALF 360
KNLLLKKIKR CERKGTESVT EEKCAVLFST SFTLGPNKLL IQLQALSLPL VVIVHGNQDN 420
NAKATILWDN AFSEMDRVPF VVAERVPWEK MCETLNLKFM AEVGTSRGLL PEHFLFLAQK 480
IFNDNSLSVE AFQHRCVSWS QFNKEILLGR GFTFWQWFDG VLDLTKRCLR SYWSDRLIIG 540
FISKQYVTSL LLNEPDGTFL LRFSDSEIGG ITIAHVIRGQ DGSSQIENIQ PFSAKDLSIR 600
SLGDRIRDLA QLKNLYPKKP KDEAFRSHYK PEQMGKDGRG YVSTTIKMTV ERDQPLPTPE 660
PQMPAMVPPY DLGMAPDASM QLSSDMGYPP QSIHSFQSLE ESMSVLPSFQ EPHLQMPPNM 720
SQITMPFDQP HPQGLLQCQS QEHAVSSPEP MLCSDVTMVE DSCLTQPVGG FPQGTWVSED 780
MYPPLMPPTE QDLTKLLLEN QGEAGGSLGS QPLLQPSPYG QSGISLSHLD LRTNPSW 837 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0019221; P:cytokine-mediated signaling pathway; IEA:Compara.
 GO:0033598; P:mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0060443; P:mammary gland morphogenesis; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0002829; P:negative regulation of type 2 immune response; IGI:MGI.
 GO:0048295; P:positive regulation of isotype switching to IgE isotypes; IGI:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0042127; P:regulation of cell proliferation; IDA:MGI.
 GO:0007165; P:signal transduction; IMP:MGI.
 GO:0002296; P:T-helper 1 cell lineage commitment; IGI:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR008967; p53-like_TF_DNA-bd.
 IPR000980; SH2.
 IPR013800; STAT_TF_alpha.
 IPR015988; STAT_TF_coiled-coil.
 IPR001217; STAT_TF_core.
 IPR013801; STAT_TF_DNA-bd.
 IPR012345; STAT_TF_DNA-bd_sub.
 IPR013799; STAT_TF_prot_interaction. 
Pfam
 PF00017; SH2
 PF01017; STAT_alpha
 PF02864; STAT_bind
 PF02865; STAT_int 
SMART
 SM00252; SH2
 SM00964; STAT_int 
PROSITE
 PS50001; SH2 
PRINTS