CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006079
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuronal acetylcholine receptor subunit alpha-3 
Protein Synonyms/Alias
  
Gene Name
 CHRNA3 
Gene Synonyms/Alias
 NACHRA3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
367SNEGNAQKPRPLYGAubiquitination[1]
448KEAIQSVKYIAENMKubiquitination[1]
455KYIAENMKAQNEAKEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. 
Sequence Annotation
 MOD_RES 413 413 Phosphoserine (By similarity).
 MOD_RES 416 416 Phosphoserine (By similarity).
 CARBOHYD 55 55 N-linked (GlcNAc...) (Potential).
 CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
 DISULFID 159 173 By similarity.
 DISULFID 223 224 Associated with receptor activation (By  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 505 AA 
Protein Sequence
MALAVSLPLA LSPPRLLLLL LLSLLPVARA SEAEHRLFER LFEDYNEIIR PVANVSDPVI 60
IHFEVSMSQL VKVDEVNQIM ETNLWLKQIW NDYKLKWNPS DYGGAEFMRV PAQKIWKPDI 120
VLYNNAVGDF QVDDKTKALL KYTGEVTWIP PAIFKSSCKI DVTYFPFDYQ NCTMKFGSWS 180
YDKAKIDLVL IGSSMNLKDY WESGEWAIIK APGYKHDIKY NCCEEIYPDI TYSLYIRRLP 240
LFYTINLIIP CLLISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI 300
PLIGEYLLFT MIFVTLSIVI TVFVLNVHYR TPTTHTMPSW VKTVFLNLLP RVMFMTRPTS 360
NEGNAQKPRP LYGAELSNLN CFSRAESKGC KEGYPCQDGM CGYCHHRRIK ISNFSANLTR 420
SSSSESVDAV LSLSALSPEI KEAIQSVKYI AENMKAQNEA KEIQDDWKYV AMVIDRIFLW 480
VFTLVCILGT AGLFLQPLMA REDA 504 
Gene Ontology
 GO:0005892; C:acetylcholine-gated channel complex; IDA:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; ISS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042166; F:acetylcholine binding; IC:UniProtKB.
 GO:0015464; F:acetylcholine receptor activity; IDA:UniProtKB.
 GO:0004889; F:acetylcholine-activated cation-selective channel activity; IDA:UniProtKB.
 GO:0007171; P:activation of transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB.
 GO:0035095; P:behavioral response to nicotine; IMP:UniProtKB.
 GO:0007626; P:locomotory behavior; ISS:UniProtKB.
 GO:0014056; P:regulation of acetylcholine secretion; ISS:UniProtKB.
 GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; ISS:UniProtKB.
 GO:0006940; P:regulation of smooth muscle contraction; ISS:UniProtKB.
 GO:0060084; P:synaptic transmission involved in micturition; IMP:UniProtKB.
 GO:0007271; P:synaptic transmission, cholinergic; ISS:UniProtKB. 
Interpro
 IPR027361; Acetylcholine_rcpt_TM.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS.
 IPR002394; Nicotinic_acetylcholine_rcpt. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR00254; NICOTINICR.
 PR00252; NRIONCHANNEL.