CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014996
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nipped-B-like protein 
Protein Synonyms/Alias
 Delangin homolog; SCC2 homolog 
Gene Name
 Nipbl 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
498FSKEVQDKDKPLKKRacetylation[1]
1009LSLDDVQKLIKDREEacetylation[2]
1034NKPSKSNKGSIDQSVubiquitination[3]
1076KRSTVNEKPKYAEISacetylation[1]
1194MMDSSTFKRFTASIEubiquitination[3]
1885KITEMCVKMIRRVNDubiquitination[3]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). 
Sequence Annotation
 REPEAT 1761 1799 HEAT 1.
 REPEAT 1837 1875 HEAT 2.
 REPEAT 1939 1978 HEAT 3.
 REPEAT 2221 2261 HEAT 4.
 REPEAT 2307 2345 HEAT 5.
 MOD_RES 150 150 Phosphoserine (By similarity).
 MOD_RES 162 162 Phosphoserine (By similarity).
 MOD_RES 256 256 Phosphoserine (By similarity).
 MOD_RES 280 280 Phosphoserine.
 MOD_RES 306 306 Phosphoserine (By similarity).
 MOD_RES 318 318 Phosphoserine (By similarity).
 MOD_RES 350 350 Phosphoserine (By similarity).
 MOD_RES 553 553 Phosphoserine.
 MOD_RES 558 558 Phosphothreonine.
 MOD_RES 713 713 Phosphothreonine (By similarity).
 MOD_RES 746 746 Phosphothreonine (By similarity).
 MOD_RES 906 906 Phosphoserine (By similarity).
 MOD_RES 1083 1083 Phosphoserine (By similarity).
 MOD_RES 1084 1084 Phosphoserine (By similarity).
 MOD_RES 1090 1090 Phosphoserine (By similarity).
 MOD_RES 1144 1144 Phosphoserine (By similarity).
 MOD_RES 1146 1146 Phosphoserine (By similarity).
 MOD_RES 1148 1148 Phosphoserine (By similarity).
 MOD_RES 1154 1154 Phosphoserine (By similarity).
 MOD_RES 1452 1452 Phosphothreonine.
 MOD_RES 1453 1453 Phosphoserine.
 MOD_RES 2503 2503 Phosphoserine (By similarity).
 MOD_RES 2505 2505 Phosphoserine (By similarity).
 MOD_RES 2507 2507 Phosphoserine (By similarity).
 MOD_RES 2509 2509 Phosphoserine (By similarity).
 MOD_RES 2652 2652 Phosphoserine.
 MOD_RES 2661 2661 Phosphothreonine.
 MOD_RES 2666 2666 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2798 AA 
Protein Sequence
MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NCLLACRDDN 60
LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG 120
MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP 180
QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR 240
HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 300
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS PTKDSTKLTL 360
RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL 420
SQQEQTAFLP ANQVPVLQQN TSVATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI 480
ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM 540
VSIDLHQAGR VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 600
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE LKQNENKTTE 660
SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP ETPKQKAESR PETPKQKSEG 720
RPETPKQKGD GRPETPKQKS EGRPETPKQK GEGRPETPKH RHENRRDSGK PSTEKKPDVS 780
KHKQDIKSDS PRLKSERAEA LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR 840
PETLRSSSRN DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 900
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF VIPKIKRDKD 960
GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ KLSLDDVQKL IKDREEKSRS 1020
SLKSIKNKPS KSNKGSIDQS VLKELPPELL AEIESTMPLC ERVKMNKRKR STVNEKPKYA 1080
EISSDEDNDS DEAFESSRKR HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY 1140
RNRSPSDSDM EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 1200
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK LSTDKTVKVL 1260
NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK SADACLTTIN IMTSPNMPKA 1320
VYIEDVIERV IQYTKFHLQN TLYPQYDPVY RVDPHGGGLL SSKAKRAKCS THKQRVIVML 1380
YNKVCDIVSS LSELLEIQLL TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE 1440
KHRQLILEEI FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 1500
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE DYRPLFENFV 1560
QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR VASLDYLGTV AARLRKDAVT 1620
SKMDQGSIER ILKQVSGGED EIQQLQKALL DYLDENTETD PSLVFSRKFY IAQWFRDTTL 1680
ETEKAMKSQK DEESSDATHH AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD 1740
TVDYDDACLI VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 1800
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER ILDTGISVRK 1860
RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV NETFQKLWFT PTPHNDKEAM 1920
TRKILNITDV VAACRDTGYD WFEQLLQNLL KSEEDSSYKP VKKACTQLVD NLVEHILKYE 1980
ESLADSDNKG VNSGRLVACI TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN 2040
VAKILELVVP LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 2100
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF DLEDFKGNSK 2160
VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL MFEQEVKNLY NSILSDKNSS 2220
VNLKIQVLKN LQTYLQEEDT RMQQADRDWK KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV 2280
LEAFFHTQSS VRHFALNVIA LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID 2340
KKYAGFIHMK AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 2400
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT LSVSGSNLLQ 2460
SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR VDSESDSDSE DDINSVMKCL 2520
PENSAPLIEF ANVSQGILLL LMLKQHLKNL CGFSDSKIQK YSPSESAKVY DKAINRKTGV 2580
HFHPKQTLDF LRSDMANSKL TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR 2640
NKAITSLLGG GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 2700
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG RKLVPWVDTI 2760
KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS 2798 
Gene Ontology
 GO:0032116; C:SMC loading complex; ISS:UniProtKB.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0036033; F:mediator complex binding; IDA:MGI.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0034613; P:cellular protein localization; IEA:Compara.
 GO:0071481; P:cellular response to X-ray; IEA:Compara.
 GO:0050890; P:cognition; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0042471; P:ear morphogenesis; IEA:Compara.
 GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:MGI.
 GO:0035261; P:external genitalia morphogenesis; IEA:Compara.
 GO:0048592; P:eye morphogenesis; IEA:Compara.
 GO:0060325; P:face morphogenesis; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IMP:MGI.
 GO:0061010; P:gall bladder development; IEA:Compara.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0034088; P:maintenance of mitotic sister chromatid cohesion; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0003151; P:outflow tract morphogenesis; IEA:Compara.
 GO:0031065; P:positive regulation of histone deacetylation; IEA:Compara.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0045778; P:positive regulation of ossification; IMP:MGI.
 GO:0048638; P:regulation of developmental growth; IEA:Compara.
 GO:0045995; P:regulation of embryonic development; IEA:Compara.
 GO:0042634; P:regulation of hair cycle; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IMP:MGI.
 GO:0061038; P:uterus morphogenesis; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR026003; Cohesin_HEAT.
 IPR024986; Nipped-B_C. 
Pfam
 PF12765; Cohesin_HEAT
 PF12830; Nipped-B_C 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS