CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase transmembrane receptor ROR2 
Protein Synonyms/Alias
 Neurotrophic tyrosine kinase, receptor-related 2 
Gene Name
 ROR2 
Gene Synonyms/Alias
 NTRKR2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
489DRFGKVYKGHLFGPAubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. 
Sequence Annotation
 DOMAIN 55 145 Ig-like C2-type.
 DOMAIN 169 303 FZ.
 DOMAIN 316 394 Kringle.
 DOMAIN 473 746 Protein kinase.
 NP_BIND 479 487 ATP (By similarity).
 ACT_SITE 615 615 Proton acceptor (By similarity).
 BINDING 507 507 ATP (By similarity).
 MOD_RES 469 469 Sulfoserine; partial.
 MOD_RES 471 471 Sulfoserine; partial.
 MOD_RES 646 646 Phosphotyrosine; by autocatalysis (By
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 318 318 N-linked (GlcNAc...) (Potential).
 DISULFID 83 135 By similarity.
 DISULFID 174 239 By similarity.
 DISULFID 182 232 By similarity.
 DISULFID 223 264 By similarity.
 DISULFID 252 300 By similarity.
 DISULFID 256 286 By similarity.
 DISULFID 316 394 By similarity.
 DISULFID 337 377 By similarity.
 DISULFID 365 389 By similarity.  
Keyword
 3D-structure; ATP-binding; Cell membrane; Complete proteome; Developmental protein; Direct protein sequencing; Disease mutation; Disulfide bond; Dwarfism; Glycoprotein; Immunoglobulin domain; Kinase; Kringle; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Sulfation; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 943 AA 
Protein Sequence
MARGSALPRR PLLCIPAVWA AAALLLSVSR TSGEVEVLDP NDPLGPLDGQ DGPIPTLKGY 60
FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRII IRKTEYGSRL 120
RIQDLDTTDT GYYQCVATNG MKTITATGVL FVRLGPTHSP NHNFQDDYHE DGFCQPYRGI 180
ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTHLS DQCSQFAIPS FCHFVFPLCD 240
ARSRTPKPRE LCRDECEVLE SDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 300
MRIGIPAERL GRYHQCYNGS GMDYRGTAST TKSGHQCQPW ALQHPHSHHL SSTDFPELGG 360
GHAYCRNPGG QMEGPWCFTQ NKNVRMELCD VPSCSPRDSS KMGILYILVP SIAIPLVIAC 420
LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLINQH KQAKLKEISL SAVRFMEELG 480
EDRFGKVYKG HLFGPAPGEQ TQAVAIKTLK DKAEGPLREE FRHEAMLRAR LQHPNVVCLL 540
GVVTKDQPLS MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHLVAQIA 600
AGMEYLSSHH VVHKDLATRN VLVYDKLNVK ISDLGLFREV YAADYYKLLG NSLLPIRWMA 660
PEAIMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRNRQV LPCPDDCPAW 720
VYALMIECWN EFPSRRPRFK DIHSRLRAWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN 780
VSNARYVGPK QKAPPFPQPQ FIPMKGQIRP MVPPPQLYVP VNGYQPVPAY GAYLPNFYPV 840
QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSMADRAALL SEGADDTQNA 900
PEDGAQSTVQ EAEEEEEGSV PETELLGDCD TLQVDEAQVQ LEA 943 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; TAS:ProtInc.
 GO:0001502; P:cartilage condensation; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0030538; P:embryonic genitalia morphogenesis; IEA:Compara.
 GO:0042472; P:inner ear morphogenesis; IEA:Compara.
 GO:0007254; P:JNK cascade; IEA:Compara.
 GO:0007275; P:multicellular organismal development; TAS:ProtInc.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
 GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IEA:Compara.
 GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara. 
Interpro
 IPR020067; Frizzled_dom.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000001; Kringle.
 IPR013806; Kringle-like.
 IPR018056; Kringle_CS.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016247; Tyr_kinase_rcpt_ROR. 
Pfam
 PF01392; Fz
 PF07679; I-set
 PF00051; Kringle
 PF07714; Pkinase_Tyr 
SMART
 SM00408; IGc2
 SM00130; KR
 SM00219; TyrKc 
PROSITE
 PS50038; FZ
 PS50835; IG_LIKE
 PS00021; KRINGLE_1
 PS50070; KRINGLE_2
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR00109; TYRKINASE.