UniProt Accession

 AURKC_HUMAN; Q9UQB9; O60681; O75442; Q6AZY8; Q6DLZ0; Q9UPK5 

Genbank Protein ID

 AF054621; AF059681; AB017332; AY661554; AC005261; CH471135; BC075064 

Genbank Nucleotide ID

 AAC25955.1; AAC77369.1; BAA76292.1; AAT64422.1; EAW72485.1; AAH75064.2 

Protein Name

 Aurora kinase C 

Protein Synonyms/Alias

 Aurora 3; Aurora/IPL1-related kinase 3; ARK-3; Aurora-related kinase 3; Aurora/IPL1/Eg2 protein 2; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C 

Gene Name

 AURKC 

Gene Synonyms/Alias

 AIE2; AIK3; AIRK3; ARK3; STK13 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	GRPLGKGKFGNVYLA	ubiquitination	[1]
130	APRGELYKELQKSEK	ubiquitination	[1]
197	HTPSLRRKTMCGTLD	acetylation	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. 

Sequence Annotation

 DOMAIN 43 293 Protein kinase.
 NP_BIND 49 57 ATP (By similarity).
 ACT_SITE 166 166 Proton acceptor (By similarity).
 BINDING 72 72 ATP (By similarity).
 MOD_RES 198 198 Phosphothreonine; by PKA (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Cell cycle; Cell division; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Meiosis; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0032133; C:chromosome passenger complex; TAS:UniProtKB.
 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0000793; C:condensed chromosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0030496; C:midbody; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0051233; C:spindle midzone; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
 GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:UniProtKB.
 GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:UniProtKB.
 GO:0000910; P:cytokinesis; TAS:ProtInc.
 GO:0016570; P:histone modification; TAS:UniProtKB.
 GO:0007126; P:meiosis; IEA:UniProtKB-KW.
 GO:0032467; P:positive regulation of cytokinesis; TAS:UniProtKB.
 GO:0051256; P:spindle midzone assembly involved in mitosis; TAS:UniProtKB. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS