CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004773
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-glutamyltranspeptidase 1 
Protein Synonyms/Alias
 GGT 1; Gamma-glutamyltransferase 1; Glutathione hydrolase 1; Leukotriene-C4 hydrolase; CD224; Gamma-glutamyltranspeptidase 1 heavy chain; Gamma-glutamyltranspeptidase 1 light chain 
Gene Name
 GGT1 
Gene Synonyms/Alias
 GGT 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
172RQGFPVGKGLAAALEubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. 
Sequence Annotation
 CARBOHYD 95 95 N-linked (GlcNAc...).
 CARBOHYD 120 120 N-linked (GlcNAc...).
 CARBOHYD 230 230 N-linked (GlcNAc...).
 CARBOHYD 266 266 N-linked (GlcNAc...).
 CARBOHYD 297 297 N-linked (GlcNAc...).
 CARBOHYD 344 344 N-linked (GlcNAc...).
 CARBOHYD 511 511 N-linked (GlcNAc...).  
Keyword
 Acyltransferase; Alternative promoter usage; Alternative splicing; Complete proteome; Direct protein sequencing; Glutathione biosynthesis; Glycoprotein; Hydrolase; Membrane; Polymorphism; Reference proteome; Sialic acid; Signal-anchor; Transferase; Transmembrane; Transmembrane helix; Zymogen. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 569 AA 
Protein Sequence
MKKKLVVLGL LAVVLVLVIV GLCLWLPSAS KEPDNHVYTR AAVAADAKQC SKIGRDALRD 60
GGSAVDAAIA ALLCVGLMNA HSMGIGGGLF LTIYNSTTRK AEVINAREVA PRLAFATMFN 120
SSEQSQKGGL SVAVPGEIRG YELAHQRHGR LPWARLFQPS IQLARQGFPV GKGLAAALEN 180
KRTVIEQQPV LCEVFCRDRK VLREGERLTL PQLADTYETL AIEGAQAFYN GSLTAQIVKD 240
IQAAGGIVTA EDLNNYRAEL IEHPLNISLG DVVLYMPSAP LSGPVLALIL NILKGYNFSR 300
ESVESPEQKG LTYHRIVEAF RFAYAKRTLL GDPKFVDVTE VVRNMTSEFF AAQLRAQISD 360
DTTHPISYYK PEFYTPDDGG TAHLSVVAED GSAVSATSTI NLYFGSKVRS PVSGILFNNE 420
MDDFSSPSIT NEFGVPPSPA NFIQPGKQPL SSMCPTIMVG QDGQVRMVVG AAGGTQITTA 480
TALAIIYNLW FGYDVKRAVE EPRLHNQLLP NVTTVERNID QAVTAALETR HHHTQIASTF 540
IAVVQAIVRT AGGWAAASDS RKGGEPAGY 569 
Gene Ontology
 GO:0031362; C:anchored to external side of plasma membrane; TAS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003840; F:gamma-glutamyltransferase activity; IDA:UniProtKB.
 GO:0036374; F:glutathione hydrolase activity; IEA:EC.
 GO:0019369; P:arachidonic acid metabolic process; TAS:Reactome.
 GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.
 GO:0006750; P:glutathione biosynthetic process; ISS:UniProtKB.
 GO:0019370; P:leukotriene biosynthetic process; IMP:UniProtKB.
 GO:0002682; P:regulation of immune system process; ISS:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; ISS:UniProtKB.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR000101; GGT_peptidase. 
Pfam
 PF01019; G_glu_transpept 
SMART
  
PROSITE
 PS00462; G_GLU_TRANSPEPTIDASE 
PRINTS
 PR01210; GGTRANSPTASE.