CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016968
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Carabin 
Protein Synonyms/Alias
 TBC1 domain family member 10C 
Gene Name
 TBC1D10C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
66LIRQREMKWVEMTSHubiquitination[1]
76EMTSHWEKTMSRRYKubiquitination[1]
91KVKMQCRKGIPSALRubiquitination[1]
347RDLQREIKAQLAQLPubiquitination[1]
388AGVRRGAKPEVPRIVubiquitination[1]
414RKPQTRGKTFHGLLTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras. 
Sequence Annotation
 DOMAIN 92 280 Rab-GAP TBC.
 REGION 406 446 Interaction with calcineurin.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 446 AA 
Protein Sequence
MAQALGEDLV QPPELQDDSS SLGSDSELSG PGPYRQADRY GFIGGSSAEP GPGHPPADLI 60
RQREMKWVEM TSHWEKTMSR RYKKVKMQCR KGIPSALRAR CWPLLCGAHV CQKNSPGTYQ 120
ELAEAPGDPQ WMETIGRDLH RQFPLHEMFV SPQGHGQQGL LQVLKAYTLY RPEQGYCQAQ 180
GPVAAVLLMH LPPEEAFWCL VQICEVYLPG YYGPHMEAVR LDAEVFMALL RRLLPHVHKH 240
LQQVGVGPLL YLPEWFLCLF ARSLPFPTVL RVWDAFLSEG ARVLFRVGLT LVRLALGTAE 300
QRGACPGLLE TLGALRAIPP AQLQEEAFMS QVHSVVLSER DLQREIKAQL AQLPDSAPGP 360
PPRPQVRLAG AQAIFEAQQL AGVRRGAKPE VPRIVVQPPE EPRPPRRKPQ TRGKTFHGLL 420
TRARGPPIEG PPRPQRGSTS FLDTRF 446 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS