UniProt Accession

 PAX8_MOUSE; Q00288; P97342; Q6GU20 

Genbank Protein ID

 X57487; X99592; X99593; X99594; X99595; X99596; X99597; X99598; AL732528; CH466542; BC020526 

Genbank Nucleotide ID

 CAA40725.1; CAA67904.1; CAA67904.1; CAA67904.1; CAA67904.1; CAA67904.1; CAA67904.1; CAA67904.1; CAM17808.1; EDL08172.1; AAH20526.1 

Protein Name

 Paired box protein Pax-8 

Protein Synonyms/Alias

  

Gene Name

 Pax8 

Gene Synonyms/Alias

 Pax-8 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
309	PHSPFAIKQETPELS	sumoylation	[1]

Reference

 [1] Pax8 protein stability is controlled by sumoylation.
 de Cristofaro T, Mascia A, Pappalardo A, D'Andrea B, Nitsch L, Zannini M.
 J Mol Endocrinol. 2009 Jan;42(1):35-46. [PMID: 18974227] 

Functional Description

 Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development. 

Sequence Annotation

 DOMAIN 9 135 Paired.  

Keyword

 Complete proteome; Developmental protein; Differentiation; DNA-binding; Nucleus; Paired box; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 457 AA 

Protein Sequence

Gene Ontology

 GO:0005667; C:transcription factor complex; TAS:MGI.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Compara.
 GO:0030154; P:cell differentiation; IMP:MGI.
 GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Compara.
 GO:0007417; P:central nervous system development; IEP:UniProtKB.
 GO:0042472; P:inner ear morphogenesis; IGI:UniProtKB.
 GO:0003337; P:mesenchymal to epithelial transition involved in metanephros morphogenesis; IEA:Compara.
 GO:0072164; P:mesonephric tubule development; IEP:UniProtKB.
 GO:0072278; P:metanephric comma-shaped body morphogenesis; IEA:Compara.
 GO:0072221; P:metanephric distal convoluted tubule development; IMP:UniProtKB.
 GO:0072289; P:metanephric nephron tubule formation; IMP:UniProtKB.
 GO:0072284; P:metanephric S-shaped body morphogenesis; IEA:Compara.
 GO:1900215; P:negative regulation of apoptotic process involved in metanephric collecting duct development; IMP:UniProtKB.
 GO:1900218; P:negative regulation of apoptotic process involved in metanephric nephron tubule development; IMP:UniProtKB.
 GO:0072305; P:negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis; IMP:UniProtKB.
 GO:0071599; P:otic vesicle development; IEA:Compara.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
 GO:0072108; P:positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; IMP:UniProtKB.
 GO:2000594; P:positive regulation of metanephric DCT cell differentiation; IMP:UniProtKB.
 GO:2000611; P:positive regulation of thyroid hormone generation; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISO:MGI.
 GO:0039003; P:pronephric field specification; IEP:UniProtKB.
 GO:0072307; P:regulation of metanephric nephron tubule epithelial cell differentiation; IMP:UniProtKB.
 GO:2000612; P:regulation of thyroid-stimulating hormone secretion; ISS:UniProtKB.
 GO:0072050; P:S-shaped body morphogenesis; IEP:UniProtKB.
 GO:0030878; P:thyroid gland development; IEP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IDA:UniProtKB. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001523; Paired_dom.
 IPR022130; Pax2_C.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00292; PAX
 PF12403; Pax2_C 

SMART

 SM00351; PAX 

PROSITE

 PS00034; PAIRED_1
 PS51057; PAIRED_2 

PRINTS

 PR00027; PAIREDBOX.