Tag | Content |
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CPLM ID | CPLM-000236 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FCH domain only protein 1 |
Protein Synonyms/Alias | |
Gene Name | FCHO1 |
Gene Synonyms/Alias | KIAA0290 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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31 | KQGPISTKELADFIR | ubiquitination | [1] | 192 | ARADFEQKMLDSALR | ubiquitination | [1] | 262 | SKGTGREKPGPLDFE | ubiquitination | [1] | 814 | ATWNLEEKRLTWRLP | ubiquitination | [1] |
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Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. |
Sequence Annotation | DOMAIN 2 83 FCH. DOMAIN 625 888 MHD. REGION 1 275 Mediates membrane-binding. REGION 267 442 Mediates interaction with the adaptor REGION 609 889 Mediates interaction with AGFG1, CALM, MOD_RES 182 182 Phosphotyrosine (By similarity). MOD_RES 184 184 Phosphoserine (By similarity). MOD_RES 616 616 Phosphoserine. |
Keyword | Alternative splicing; Coated pit; Coiled coil; Complete proteome; Endocytosis; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 889 AA |
Protein Sequence | MSYFGEHFWG EKNHGFEVLY HSVKQGPIST KELADFIRER ATIEETYSKA MAKLSKLASN 60 GTPMGTFAPL WEVFRVSSDK LALCHLELTR KLQDLIKDVL RYGEEQLKTH KKCKEEVVST 120 LDAVQVLSGV SQLLPKSREN YLNRCMDQER LRRESTSQKE MDKAETKTKK AAESLRRSVE 180 KYNSARADFE QKMLDSALRF QAMEETHLRH MKALLGSYAH SVEDTHVQIG QVHEEFKQNI 240 ENVSVEMLLR KFAESKGTGR EKPGPLDFEA YSAAALQEAM KRLRGAKAFR LPGLSRRERE 300 PEPPAAVDFL EPDSGTCPEV DEEGFTVRPD VTQNSTAEPS RFSSSDSDFD DEEPRKFYVH 360 IKPAPARAPA CSPEAAAAQL RATAGSLILP PGPGGTMKRH SSRDAAGKPQ RPRSAPRTSS 420 CAERLQSEEQ VSKNLFGPPL ESAFDHEDFT GSSSLGFTSS PSPFSSSSPE NVEDSGLDSP 480 SHAAPGPSPD SWVPRPGTPQ SPPSCRAPPP EARGIRAPPL PDSPQPLASS PGPWGLEALA 540 GGDLMPAPAD PTAREGLAAP PRRLRSRKVS CPLTRSNGDL SRSLSPSPLG SSAASTALER 600 PSFLSQTGHG VSRGPSPVVL GSQDALPIAT AFTEYVHAYF RGHSPSCLAR VTGELTMTFP 660 AGIVRVFSGT PPPPVLSFRL VHTTAIEHFQ PNADLLFSDP SQSDPETKDF WLNMAALTEA 720 LQRQAEQNPT ASYYNVVLLR YQFSRPGPQS VPLQLSAHWQ CGATLTQVSV EYGYRPGATA 780 VPTPLTNVQI LLPVGEPVTN VRLQPAATWN LEEKRLTWRL PDVSEAGGSG RLSASWEPLS 840 GPSTPSPVAA QFTSEGTTLS GVDLELVGSG YRMSLVKRRF ATGMYLVSC 889 |
Gene Ontology | GO:0005905; C:coated pit; IDA:UniProtKB. GO:0005886; C:plasma membrane; IDA:UniProtKB. GO:0035612; F:AP-2 adaptor complex binding; IDA:MGI. GO:0048268; P:clathrin coat assembly; IMP:UniProtKB. GO:0072583; P:clathrin-mediated endocytosis; IMP:UniProtKB. |
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