CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045168
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Casein kinase I isoform gamma-2 
Protein Synonyms/Alias
  
Gene Name
 CSNK1G2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
216EYIDPETKKHIPYREubiquitination[1]
271SLPWQGLKADTLKERubiquitination[1, 2, 3, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 299 AA 
Protein Sequence
XSKAGGGRSS HGIRSSGTSS GVLMVGPNFR VGKKIGCGNF GELRLGKNLY TNEYVAIKLV 60
SRPLHPTPAD VPPRDFRAAT RSPGDSLLCP QEPIKSRAPQ LHLEYRFYKQ LSATEGVPQV 120
YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFTLKTVLMI AIQLITRMEY VHTKSLIYRD 180
VKPENFLVGR PGTKRQHAIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 240
GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRATP IEVLCENFP 299 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS