| Tag | Content |
|---|
| CPLM ID | CPLM-001890 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Somatotropin |
Protein Synonyms/Alias | Growth hormone |
Gene Name | GH1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Sus scrofa (Pig) |
NCBI Taxa ID | 9823 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 137 | TSDRVYEKLKDLEEG | acetylation | [1] | | 169 | ILKQTYDKFDTNLRS | acetylation | [1] | | 196 | CFKKDLHKAETYLRV | acetylation | [1] |
|
Reference | [1] Isolation of Escherichia coli synthesized recombinant eukaryotic proteins that contain epsilon-N-acetyllysine. Violand BN, Schlittler MR, Lawson CQ, Kane JF, Siegel NR, Smith CE, Kolodziej EW, Duffin KL. Protein Sci. 1994 Jul;3(7):1089-97. [ PMID: 7920255] |
Functional Description | Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. |
Sequence Annotation | METAL 45 45 Zinc (By similarity).
METAL 198 198 Zinc (By similarity).
MOD_RES 131 131 Phosphoserine (By similarity).
DISULFID 78 189 By similarity.
DISULFID 206 214 |
Keyword | Complete proteome; Direct protein sequencing; Disulfide bond; Hormone; Metal-binding; Phosphoprotein; Reference proteome; Secreted; Signal; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 216 AA |
Protein Sequence | MAAGPRTSAL LAFALLCLPW TREVGAFPAM PLSSLFANAV LRAQHLHQLA ADTYKEFERA 60
YIPEGQRYSI QNAQAAFCFS ETIPAPTGKD EAQQRSDVEL LRFSLLLIQS WLGPVQFLSR 120
VFTNSLVFGT SDRVYEKLKD LEEGIQALMR ELEDGSPRAG QILKQTYDKF DTNLRSDDAL 180
LKNYGLLSCF KKDLHKAETY LRVMKCRRFV ESSCAF 216 |
Gene Ontology | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL. GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |