CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011921
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 
Protein Synonyms/Alias
 BRG1-associated factor 47; BAF47; Integrase interactor 1 protein; SNF5 homolog; hSNF5 
Gene Name
 SMARCB1 
Gene Synonyms/Alias
 BAF47; INI1; SNF5L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
97ILDGNDEKYKAVSISubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene. 
Sequence Annotation
 REPEAT 186 245 1.
 REPEAT 259 319 2.
 REGION 106 183 DNA-binding (Potential).
 REGION 183 243 HIV-1 integrase-binding.
 REGION 186 319 2 X approximate tandem repeats.
 REGION 186 245 MYC-binding.
 REGION 304 318 Interaction with PPP1R15A.
 MOD_RES 129 129 Phosphoserine.  
Keyword
 Activator; Alternative splicing; Cell cycle; Chromatin regulator; Complete proteome; Disease mutation; Host-virus interaction; Mental retardation; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 385 AA 
Protein Sequence
MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER 60
KKIVASSHDH GYTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS 120
QWVPTLPNSS HHLDAVPCST TINRNRMGRD KKRTFPLCFD DHDPAVIHEN ASQPEVLVPI 180
RLDMEIDGQK LRDAFTWNMN EKLMTPEMFS EILCDDLDLN PLTFVPAIAS AIRQQIESYP 240
TDSILEDQSD QRVIIKLNIH VGNISLVDQF EWDMSEKENS PEKFALKLCS ELGLGGEFVT 300
TIAYSIRGQL SWHQKTYAFS ENPLPTVEIA IRNTGDADQW CPLLETLTDA EMEKKIRDQD 360
RNTRRMRRLA NTAPAW 376 
Gene Ontology
 GO:0071565; C:nBAF complex; ISS:UniProtKB.
 GO:0071564; C:npBAF complex; ISS:UniProtKB.
 GO:0000228; C:nuclear chromosome; IEA:InterPro.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:ProtInc.
 GO:0016514; C:SWI/SNF complex; IDA:UniProtKB.
 GO:0001741; C:XY body; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IMP:BHF-UCL.
 GO:0043044; P:ATP-dependent chromatin remodeling; IBA:RefGenome.
 GO:0001835; P:blastocyst hatching; IEA:Compara.
 GO:0030154; P:cell differentiation; IBA:RefGenome.
 GO:0015074; P:DNA integration; TAS:ProtInc.
 GO:0006281; P:DNA repair; IBA:RefGenome.
 GO:0044772; P:mitotic cell cycle phase transition; IBA:RefGenome.
 GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0006337; P:nucleosome disassembly; IDA:BHF-UCL.
 GO:0043923; P:positive regulation by host of viral transcription; IMP:BHF-UCL.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045090; P:retroviral genome replication; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR006939; SNF5.
 IPR017393; SWI_SNF_chromatin_remodel_cplx. 
Pfam
 PF04855; SNF5 
SMART
  
PROSITE
  
PRINTS