UniProt Accession

 VAMP2_HUMAN; P63027; P19065; Q9BUC2 

Genbank Protein ID

 M36205; M36201; M36202; M36203; M36204; AJ225044; AF135372; AK289555; CH471108; BC002737; BC019608; BC033870 

Genbank Nucleotide ID

 AAA60604.1; AAA60604.1; AAA60604.1; AAA60604.1; AAA60604.1; CAA12385.1; AAF15551.1; BAF82244.1; EAW90087.1; AAH02737.3; AAH19608.1; AAH33870.1 

Protein Name

 Vesicle-associated membrane protein 2 

Protein Synonyms/Alias

 VAMP-2; Synaptobrevin-2 

Gene Name

 VAMP2 

Gene Synonyms/Alias

 SYB2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	IMRVNVDKVLERDQK	ubiquitination	[1]
59	KVLERDQKLSELDDR	ubiquitination	[1]
83	QFETSAAKLKRKYWW	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the targeting and/or fusion of transport vesicles to their target membrane. 

Sequence Annotation

 DOMAIN 31 91 v-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 75 75 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Cell junction; Coiled coil; Complete proteome; Cytoplasmic vesicle; Membrane; Phosphoprotein; Reference proteome; Synapse; Synaptosome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 116 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0061202; C:clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; TAS:Reactome.
 GO:0060203; C:clathrin-sculpted glutamate transport vesicle membrane; TAS:Reactome.
 GO:0070083; C:clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0030667; C:secretory granule membrane; TAS:Reactome.
 GO:0031201; C:SNARE complex; IDA:UniProtKB.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0070044; C:synaptobrevin 2-SNAP-25-syntaxin-1a complex; IEA:Compara.
 GO:0070032; C:synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; IEA:Compara.
 GO:0005802; C:trans-Golgi network; IEA:Compara.
 GO:0042589; C:zymogen granule membrane; IEA:Compara.
 GO:0005543; F:phospholipid binding; IEA:Compara.
 GO:0017156; P:calcium ion-dependent exocytosis; IEA:Compara.
 GO:0006944; P:cellular membrane fusion; IEA:Compara.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0014047; P:glutamate secretion; TAS:Reactome.
 GO:0043001; P:Golgi to plasma membrane protein transport; IEA:Compara.
 GO:0007269; P:neurotransmitter secretion; TAS:Reactome.
 GO:0090316; P:positive regulation of intracellular protein transport; IEA:Compara.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0017157; P:regulation of exocytosis; IEA:Compara.
 GO:0050796; P:regulation of insulin secretion; TAS:Reactome.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0016079; P:synaptic vesicle exocytosis; IEA:Compara. 

Interpro

 IPR001388; Synaptobrevin.
 IPR016444; Synaptobrevin_met/fun. 

Pfam

 PF00957; Synaptobrevin 

SMART

  

PROSITE

 PS00417; SYNAPTOBREVIN
 PS50892; V_SNARE 

PRINTS

 PR00219; SYNAPTOBREVN.