CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025570
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leukotriene A-4 hydrolase 
Protein Synonyms/Alias
 Leukotriene A4 hydrolase 
Gene Name
 Lta4h 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
58RSLTLDTKDLTIEKVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 611 AA 
Protein Sequence
MPEVADTCSL ASPASVCRTQ HLHLRCSVDF ARRALTGTAA LTVQSQEDNL RSLTLDTKDL 60
TIEKVVINGQ EVKYTLGESQ GYKGSPMEIS LPIALSKNQE VVIEISFETS PKSSALQWLT 120
PEQTSGKQHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGEAP 180
DPEDPSRKIY RFNQRVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES 240
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH 300
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FHALGGWGEL QNTIKTFGES 360
HPFTKLVVDL KDVDPDVAYS SIPYEKGFAL LFYLEQLLGG PEVFLGFLKA YVEKFSYQSV 420
TTDDWKSFLY AHFKDKVDLL NQVDWNAWLY APGLPPVKPN YDVTLTNACI ALSQRWVTAK 480
EEDLNSFSIE DLKDLSSHQL NEFLAQVLQK APLPLGHIKR MQEVYNFNAI NNSEIRFRWL 540
RLCIQSKWEE AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKACMHPVT 600
AMLVGKDLKV D 611 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0004177; F:aminopeptidase activity; IEA:Compara.
 GO:0004463; F:leukotriene-A4 hydrolase activity; IEA:Compara.
 GO:0008237; F:metallopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:Compara.
 GO:0019370; P:leukotriene biosynthetic process; IEA:Compara.
 GO:0043171; P:peptide catabolic process; IEA:Compara.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR012777; Leukotriene_A4_hydrolase.
 IPR001930; Peptidase_M1.
 IPR015211; Peptidase_M1_C.
 IPR014782; Peptidase_M1_N. 
Pfam
 PF09127; Leuk-A4-hydro_C
 PF01433; Peptidase_M1 
SMART
  
PROSITE
  
PRINTS
 PR00756; ALADIPTASE.