UniProt Accession

 YACG_ECOLI; P0A8H8; P36681; P75644; Q8KJQ7 

Genbank Protein ID

 U00096; AP009048; X04831 

Genbank Nucleotide ID

 AAC73212.1; BAB96668.2 

Protein Name

 DNA gyrase inhibitor YacG 

Protein Synonyms/Alias

  

Gene Name

 yacG 

Gene Synonyms/Alias

 b0101; JW5008 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
64	DDWSEEPKQ******	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. 

Sequence Annotation

 METAL 9 9 Zinc.
 METAL 12 12 Zinc.
 METAL 28 28 Zinc.
 METAL 32 32 Zinc.  

Keyword

 3D-structure; Complete proteome; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 65 AA 

Protein Sequence

Gene Ontology

 GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IDA:EcoCyc.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR005584; DNA_gyrase_inhibitor_YacG.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF03884; DUF329 

SMART

  

PROSITE

  

PRINTS