UniProt Accession

 APT_ECOLI; P69503; P07672; P09993; P77121; Q2MBV8 

Genbank Protein ID

 M14040; X04487; U82664; U00096; AP009048; M38777 

Genbank Nucleotide ID

 AAA23455.1; CAA28173.1; AAB40223.1; AAC73571.1; BAE76248.1; AAA23456.1 

Protein Name

 Adenine phosphoribosyltransferase 

Protein Synonyms/Alias

 APRT 

Gene Name

 apt 

Gene Synonyms/Alias

 b0469; JW0458 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
16	EYLKNSIKSIQDYPK	acetylation	[1]
23	KSIQDYPKPGILFRD	acetylation	[1, 2]
39	TSLLEDPKAYALSID	acetylation	[1]
169	GGEQRLEKQGITSYS	acetylation	[1, 2]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Glycosyltransferase; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 183 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0003999; F:adenine phosphoribosyltransferase activity; IDA:EcoCyc.
 GO:0042802; F:identical protein binding; IDA:EcoCyc.
 GO:0000287; F:magnesium ion binding; IDA:EcoCyc.
 GO:0006168; P:adenine salvage; IDA:EcoCyc.
 GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
 GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW. 

Interpro

 IPR005764; Ade_phspho_trans.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS