| Tag | Content |
|---|
| CPLM ID | CPLM-015603 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Beta-galactoside alpha-2,6-sialyltransferase 2 |
Protein Synonyms/Alias | Alpha 2,6-ST 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; ST6Gal II; ST6GalII; Sialyltransferase 2 |
Gene Name | St6gal2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 57 | GLLPVQGKQRVIMGA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids (By similarity). |
Sequence Annotation | CARBOHYD 303 303 N-linked (GlcNAc...) (Potential).
CARBOHYD 333 333 N-linked (GlcNAc...) (Potential).
CARBOHYD 521 521 N-linked (GlcNAc...) (Potential).
DISULFID 249 515 By similarity.
DISULFID 292 444 By similarity.
DISULFID 462 473 By similarity. |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 525 AA |
Protein Sequence | MKPHLKQWRQ RMLFAIFVWG LLFLAIFIYF TNSNPAAPMP SSFSFLESRG LLPVQGKQRV 60
IMGALQEPSL PRSLEPSKVL MDGHSASPFN SWPGDPQKGD QAQDGFDNGD EFFTSQVGRK 120
SQSAFYPEED NYFFVAGQPG LYHHRQGALG LPSPGESSWQ SGPGQPKQEK LRHPRRGSLP 180
EEAYDSDMLS TSMSRAFLYR LWKGTVSSKM LNPRLQKAMR YYMSFNKHGV RFSRRGRREA 240
RRTGPELLCE MRKRVRVRTL DGKEAPFSGL GWRPLVPGVP LSQLHPRGLR SCAVVMSAGA 300
ILNSSLGEEI DSHDAVLRFN SAPTRGYEKD VGNKTTVRII NSQILANPSH HFIDSSLYKD 360
VILVAWDPAP YSANLNLWYK KPDYNLFTPY IQHRLKYPTQ PFYILHPKFI WQLWDIIQEN 420
TREKIQPNPP SSGFIGILVM MSMCQEVHVY EYIPSVRQTE LCHYHELYYD AACTLGAYHP 480
LLYEKLLVQR LNTGTQADLH HKGKVVLPGF QTLRCPVTRP NNTNT 525 |
Gene Ontology | GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0003835; F:beta-galactoside alpha-2,6-sialyltransferase activity; ISS:UniProtKB. GO:0009311; P:oligosaccharide metabolic process; ISS:UniProtKB. GO:0006486; P:protein glycosylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |