CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032076
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 H(+)/Cl(-) exchange transporter 4 
Protein Synonyms/Alias
 cDNA FLJ50190, highly similar to Chloride channel protein 4 
Gene Name
 CLCN4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
646LLGIITKKDVLRHMAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 666 AA 
Protein Sequence
MTDLKEGVCL SAFWYSHEQC CWTSNETTFE DRDKCPLWQK WSELLVNQSE GASAYILNYL 60
MYILWALLFA FLAVSLVRVF APYACGSGIP EIKTILSGFI IRGYLGKWTL LIKTVTLVLV 120
VSSGLSLGKE GPLVHVACCC GNFFSSLFSK YSKNEGKRRE VLSAAAAAGV SVAFGAPIGG 180
VLFSLEEVSY YFPLKTLWRS FFAALVAAFT LRSINPFGNS RLVLFYVEYH TPWYMAELFP 240
FILLGVFGGL WGTLFIRCNI AWCRRRKTTR LGKYPVLEVI VVTAITAIIA YPNPYTRQST 300
SELISELFND CGALESSQLC DYINDPNMTR PVDDIPDRPA GVGVYTAMWQ LALALIFKIV 360
VTIFTFGMKI PSGLFIPSMA VGAIAGRMVG IGVEQLAYHH HDWIIFRNWC RPGADCVTPG 420
LYAMVGAAAC LGGVTRMTVS LVVIMFELTG GLEYIVPLMA AAVTSKWVAD AFGKEGIYEA 480
HIHLNGYPFL DVKDEFTHRT LATDVMRPRR GEPPLSVLTQ DSMTVEDVET LIKETDYNGF 540
PVVVSRDSER LIGFAQRREL ILAIKNARQR QEGIVSNSIM YFTEEPPELP ANSPHPLKLR 600
RILNLSPFTV TDHTPMETVV DIFRKLGLRQ CLVTRSGRLL GIITKKDVLR HMAQMANQDP 660
ESIMFN 666 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro. 
Interpro
 IPR014743; Cl-channel_core.
 IPR001807; Cl-channel_volt-gated.
 IPR002246; Cl_channel-4.
 IPR000644; Cysta_beta_synth_core. 
Pfam
 PF00571; CBS
 PF00654; Voltage_CLC 
SMART
 SM00116; CBS 
PROSITE
 PS51371; CBS 
PRINTS
 PR00762; CLCHANNEL.
 PR01115; CLCHANNEL4.