CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021668
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 14 homolog 
Protein Synonyms/Alias
 Zfp-14; Zinc finger protein 531 
Gene Name
 ZFP14 
Gene Synonyms/Alias
 KIAA1559; ZNF531 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
128NDWECKSKIEGEKEQubiquitination[1]
133KSKIEGEKEQQEGYFubiquitination[1]
154SEKMTTYKRHNFLTEubiquitination[2]
235YECKECGKAFTVLQEubiquitination[1]
310QRLHTAEKLYECKECubiquitination[1]
315AEKLYECKECGKAFVubiquitination[1]
319YECKECGKAFVCGPDubiquitination[1]
332PDLRVHQKIHFGEKPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 6 78 KRAB.
 ZN_FING 172 194 C2H2-type 1.
 ZN_FING 200 222 C2H2-type 2.
 ZN_FING 228 250 C2H2-type 3.
 ZN_FING 256 278 C2H2-type 4.
 ZN_FING 284 306 C2H2-type 5.
 ZN_FING 312 334 C2H2-type 6.
 ZN_FING 340 362 C2H2-type 7.
 ZN_FING 368 390 C2H2-type 8.
 ZN_FING 396 418 C2H2-type 9.
 ZN_FING 424 446 C2H2-type 10.
 ZN_FING 452 474 C2H2-type 11.
 ZN_FING 480 502 C2H2-type 12.
 ZN_FING 508 530 C2H2-type 13.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 533 AA 
Protein Sequence
MAHGSVTFRD VAIDFSQEEW EFLDPAQRDL YRDVMWENYS NFISLGPSIS KPDVITLLDE 60
ERKEPGMVVR EGTRRYCPDL ESRYRTNTLS PEKDIYEIYS FQWDIMERIK SYSLQGSIFR 120
NDWECKSKIE GEKEQQEGYF GQVKITSEKM TTYKRHNFLT EYQIVHNGEK VYECKECRKT 180
FIRRSTLSQH LRIHTGEKPY KCKECGQAFR QRAHLIRHHK LHTGEKPYEC KECGKAFTVL 240
QELTQHQRLH TGEKPYECKE CGKAFRVHQQ LARHQRIHTG EKPYECKDCG KTFRQCTHLT 300
RHQRLHTAEK LYECKECGKA FVCGPDLRVH QKIHFGEKPY ECKECGKAFR ICQQLTVHQS 360
IHTGEKPYEC KECGKTFRLR QQLVRHQRIH TREKPYECME CWKTFSSYSQ LISHQSIHIG 420
ERPYECEECG KAFRLLSQLT QHQSIHTGEK PYECKECRKP FRLLSQLTQH QSIHTGEKPY 480
ECKECGKAFR LYSFLTQHQR IHTGEKPYKC KECKKAFRQH SHLTQHQKIH NGI 533 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS