CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Histidine permease 
Protein Synonyms/Alias
  
Gene Name
 HIP1 
Gene Synonyms/Alias
 YGR191W; G7572 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
19ADVVDGFKPATSPAFubiquitination[1]
30SPAFENEKESTTFVTubiquitination[1, 2]
42FVTELTSKTDSAFPLubiquitination[1]
52SAFPLSSKDSPGINQubiquitination[1]
88INNTNLSKDLSVRHLubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 
Functional Description
 High-affinity permease for histidine. 
Sequence Annotation
 MOD_RES 76 76 Phosphothreonine.  
Keyword
 Amino-acid transport; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 603 AA 
Protein Sequence
MPRNPLKKEY WADVVDGFKP ATSPAFENEK ESTTFVTELT SKTDSAFPLS SKDSPGINQT 60
TNDITSSDRF RRNEDTEQED INNTNLSKDL SVRHLLTLAV GGAIGTGLYV NTGAALSTGG 120
PASLVIDWVI ISTCLFTVIN SLGELSAAFP VVGGFNVYSM RFIEPSFAFA VNLNYLAQWL 180
VLLPLELVAA SITIKYWNDK INSDAWVAIF YATIALANML DVKSFGETEF VLSMIKILSI 240
IGFTILGIVL SCGGGPHGGY IGGKYWHDPG AFVGHSSGTQ FKGLCSVFVT AAFSYSGIEM 300
TAVSAAESKN PRETIPKAAK RTFWLITASY VTILTLIGCL VPSNDPRLLN GSSSVDAASS 360
PLVIAIENGG IKGLPSLMNA IILIAVVSVA NSAVYACSRC MVAMAHIGNL PKFLNRVDKR 420
GRPMNAILLT LFFGLLSFVA ASDKQAEVFT WLSALSGLST IFCWMAINLS HIRFRQAMKV 480
QERSLDELPF ISQTGVKGSW YGFIVLFLVL IASFWTSLFP LGGSGASAES FFEGYLSFPI 540
LIVCYVGHKL YTRNWTLMVK LEDMDLDTGR KQVDLTLRRE EMRIERETLA KRSFVTRFLH 600
FWC 603 
Gene Ontology
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005886; C:plasma membrane; IMP:SGD.
 GO:0005291; F:high affinity L-histidine transmembrane transporter activity; IMP:SGD.
 GO:0006828; P:manganese ion transport; IMP:SGD. 
Interpro
 IPR004841; AA-permease_dom.
 IPR002293; AA/rel_permease1.
 IPR004762; Amino_acid_permease_fungi.
 IPR004840; Amoino_acid_permease_CS. 
Pfam
 PF00324; AA_permease 
SMART
  
PROSITE
 PS00218; AMINO_ACID_PERMEASE_1 
PRINTS