CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015452
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab11 family-interacting protein 1 
Protein Synonyms/Alias
 Rab11-FIP1; Rab-coupling protein 
Gene Name
 RAB11FIP1 
Gene Synonyms/Alias
 RCP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
800EMGLNLRKDQKKTKKacetylation[1]
803LNLRKDQKKTKKRVSacetylation[1]
1212NNEVMMKKYSPSDPAubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis. 
Sequence Annotation
 DOMAIN 5 108 C2.
 DOMAIN 1211 1273 FIP-RBD.
 REGION 1219 1283 Necessary for interaction with RAB4A and
 MOD_RES 202 202 Phosphoserine.
 MOD_RES 300 300 Phosphoserine.
 MOD_RES 339 339 Phosphoserine.
 MOD_RES 343 343 Phosphoserine.
 MOD_RES 345 345 Phosphoserine.
 MOD_RES 356 356 Phosphoserine (By similarity).
 MOD_RES 357 357 Phosphoserine.
 MOD_RES 382 382 Phosphoserine (By similarity).
 MOD_RES 435 435 Phosphoserine.
 MOD_RES 477 477 Phosphoserine.
 MOD_RES 545 545 Phosphoserine.
 MOD_RES 758 758 Phosphoserine.
 MOD_RES 1135 1135 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasmic vesicle; Endosome; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1283 AA 
Protein Sequence
MSLMVSAGRG LGAVWSPTHV QVTVLQARGL RAKGPGGTSD AYAVIQVGKE KYATSVSERS 60
LGAPVWREEA TFELPSLLSS GPAAAATLQL TVLHRALLGL DKFLGRAEVD LRDLHRDQGR 120
RKTQWYKLKS KPGKKDKERG EIEVDIQFMR NNMTASMFDL SMKDKSRNPF GKLKDKIKGK 180
NKDSGSDTAS AIIPSTTPSV DSDDESVVKD KKKKSKIKTL LSKSNLQKTP LSQSMSVLPT 240
SKPEKVLLRP GDFQSQWDED DNEDESSSAS DVMSHKRTAS TDLKQLNQVN FTLPKKEGLS 300
FLGGLRSKND VLSRSNVCIN GNHVYLEQPE AKGEIKDSSP SSSPSPKGFR KKHLFSSTEN 360
LAAGSWKEPA EGGGLSSDRQ LSESSTKDSL KSMTLPSYRP APLVSGDLRE NMAPANSEAT 420
KEAKESKKPE SRRSSLLSLM TGKKDVAKGS EGENPLTVPG REKEGMLMGV KPGEDASGPA 480
EDLVRRSEKD TAAVVSRQGS SLNLFEDVQI TEPEAEPESK SEPRPPISSP RAPQTRAVKP 540
RLEVSPEAQP TARLPSPTDS PSSLPPLPSS SGQASVPSEL GHGADTQSSE SPSVFSSLSS 600
PIAAPISTST PIESWPLVDR GQAKSEGPPL LPKAELQTES LTPVPNSGSS ALGSLFKQPS 660
FPANKGTEDS LMGRTRETGT EKNTSSLELE ESLPEQPETG RQEEELPRFP CKKQDYSPSS 720
GEAQEVPFAL SLSSDGAVSP VGELAAGGDR DLESQAGSLV ESKARDAAEE VAPPLPMGAS 780
VPSIDSMMRK LEEMGLNLRK DQKKTKKRVS FSEQLFTEEA VAGAALLVEG HSSCPQELNP 840
AWSVAGNASD GEPPESPHAE DSERESVTTP GPATCGAPAS PADHLLLPSQ EESFSEVPMS 900
EASSAKDTPL FRMEGEDALV TQYQSKASDH EGLLSDPLSD LQLVSDFKSP IMADLNLSLP 960
SIPEVASDDE RIDQVEDDGD QVEDDGETAK SSTLDIGALS LGLVVPCPER GKGPSGEADR 1020
LVLGEGLCDF RLQAPQASVT APSEQTTEFG IHKPHLGKSS SLDKQLPGPS GGEEEKPMGN 1080
GSPSPPPGTS LDNPVPSPSP SEIFPVTHSF PSSAHSDTHH TSTAESQKKA TAEGSAGRVE 1140
NFGKRKPLLQ AWVSPSETHP VSAQPGAGTG SAKHRLHPVK PMNAMATKVA NCSLGTATII 1200
SENLNNEVMM KKYSPSDPAF AYAQLTHDEL IQLVLKQKET ISKKEFQVRE LEDYIDNLLV 1260
RVMEETPNIL RIPTQVGKKA GKM 1283 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF00168; C2
 PF09457; RBD-FIP 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2
 PS51511; FIP_RBD 
PRINTS