CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020048
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Apolipoprotein L2 
Protein Synonyms/Alias
 Apolipoprotein L-II; ApoL-II 
Gene Name
 APOL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58ELRKALNKLASHMVMubiquitination[1]
83QHRQWFLKEFPRLKRubiquitination[1, 2, 3, 4]
193QSGTNVAKVMKEFVGubiquitination[1, 2, 3, 4]
303KHLLEGAKSESAEELubiquitination[3]
320RAQELEGKLNFLTKIubiquitination[1, 2, 3, 4]
326GKLNFLTKIHEMLQPubiquitination[2, 3, 4]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles. 
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 250 250 Phosphoserine.  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 337 AA 
Protein Sequence
MNPESSIFIE DYLKYFQDQV SRENLLQLLT DDEAWNGFVA AAELPRDEAD ELRKALNKLA 60
SHMVMKDKNR HDKDQQHRQW FLKEFPRLKR ELEDHIRKLR ALAEEVEQVH RGTTIANVVS 120
NSVGTTSGIL TLLGLGLAPF TEGISFVLLD TGMGLGAAAA VAGITCSVVE LVNKLRARAQ 180
ARNLDQSGTN VAKVMKEFVG GNTPNVLTLV DNWYQVTQGI GRNIRAIRRA RANPQLGAYA 240
PPPHIIGRIS AEGGEQVERV VEGPAQAMSR GTMIVGAATG GILLLLDVVS LAYESKHLLE 300
GAKSESAEEL KKRAQELEGK LNFLTKIHEM LQPGQDQ 337 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; NAS:UniProtKB.
 GO:0005576; C:extracellular region; IEA:InterPro.
 GO:0008035; F:high-density lipoprotein particle binding; NAS:UniProtKB.
 GO:0008289; F:lipid binding; NAS:UniProtKB.
 GO:0005102; F:receptor binding; NAS:UniProtKB.
 GO:0006953; P:acute-phase response; NAS:UniProtKB.
 GO:0008203; P:cholesterol metabolic process; NAS:UniProtKB.
 GO:0006869; P:lipid transport; NAS:UniProtKB.
 GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
 GO:0060135; P:maternal process involved in female pregnancy; NAS:UniProtKB.
 GO:0007275; P:multicellular organismal development; NAS:UniProtKB. 
Interpro
 IPR008405; ApoL. 
Pfam
 PF05461; ApoL 
SMART
  
PROSITE
  
PRINTS