UniProt Accession

 HXT6_YEAST; P39003; D6VSX4 

Genbank Protein ID

 Z31691; U51032; BK006938 

Genbank Nucleotide ID

 CAA83496.1; AAB64779.1; DAA12184.1 

Protein Name

 High-affinity hexose transporter HXT6 

Protein Synonyms/Alias

  

Gene Name

 HXT6 

Gene Synonyms/Alias

 YDR343C; D9651.12 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
40	KAERDEIKAYGEGEE	ubiquitination	[1, 2]
198	LISEVSPKHLRGTLV	ubiquitination	[2]
268	RYLAEVGKIEEAKRS	ubiquitination	[1, 2]
560	EEMAHDDKPLYKRMF	ubiquitination	[3, 4, 5]

Reference

 [1] Systematic approach for validating the ubiquitinated proteome.
 Seyfried NT, Xu P, Duong DM, Cheng D, Hanfelt J, Peng J.
 Anal Chem. 2008 Jun 1;80(11):4161-9. [PMID: 18433149]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] A proteomics approach to understanding protein ubiquitination.
 Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP.
 Nat Biotechnol. 2003 Aug;21(8):921-6. [PMID: 12872131]
 [4] Computational identification of ubiquitylation sites from protein sequences.
 Tung CW, Ho SY.
 BMC Bioinformatics. 2008 Jul 15;9:310. [PMID: 18625080]
 [5] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

 High-affinity glucose transporter. 

Sequence Annotation

 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 CARBOHYD 228 228 N-linked (GlcNAc...) (Potential).
 CROSSLNK 560 560 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Complete proteome; Glycoprotein; Isopeptide bond; Membrane; Reference proteome; Repeat; Sugar transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 570 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005353; F:fructose transmembrane transporter activity; TAS:SGD.
 GO:0005355; F:glucose transmembrane transporter activity; IDA:SGD.
 GO:0015578; F:mannose transmembrane transporter activity; TAS:SGD. 

Interpro

 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 

Pfam

 PF00083; Sugar_tr 

SMART

  

PROSITE

 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 

PRINTS

 PR00171; SUGRTRNSPORT.