Tag | Content |
---|
CPLM ID | CPLM-008331 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipopolysaccharide-responsive and beige-like anchor protein |
Protein Synonyms/Alias | Beige-like protein; CDC4-like protein |
Gene Name | LRBA |
Gene Synonyms/Alias | BGL; CDC4L; LBA |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
---|
200 | VLKHMPQKYGPDAFF | ubiquitination | [1] | 820 | IQNPQILKVIATLLR | ubiquitination | [1] | 1259 | DTERLELKASPNVEA | ubiquitination | [1] | 1487 | PLGKSAAKSPVDIVT | ubiquitination | [1] | 1776 | GSRSSNAKLPSVPTV | ubiquitination | [1] | 2260 | TNFRDLSKPIGALNP | ubiquitination | [1] | 2268 | PIGALNPKRAAFFAE | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules (By similarity). |
Sequence Annotation | REPEAT 1301 1343 WD 1. DOMAIN 2200 2489 BEACH. REPEAT 2591 2633 WD 2. REPEAT 2636 2679 WD 3. REPEAT 2695 2735 WD 4. REPEAT 2777 2816 WD 5. REPEAT 2819 2858 WD 6. MOD_RES 2 2 N-acetylalanine. MOD_RES 10 10 Phosphoserine. MOD_RES 904 904 Phosphotyrosine (By similarity). MOD_RES 979 979 Phosphoserine. MOD_RES 1005 1005 Phosphoserine (By similarity). MOD_RES 1100 1100 Phosphoserine. MOD_RES 1139 1139 Phosphoserine. MOD_RES 1488 1488 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Disease mutation; Endoplasmic reticulum; Golgi apparatus; Lysosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2863 AA |
Protein Sequence | MASEDNRVPS PPPTGDDGGG GGREETPTEG GALSLKPGLP IRGIRMKFAV LTGLVEVGEV 60 SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SINCMVDLLE KCDITCQAEV WSMFTAILKK 120 SIRNLQVCTE VGLVEKVLGK IEKVDNMIAD LLVDMLGVLA SYNLTVRELK LFFSKLQGDK 180 GRWPPHAGKL LSVLKHMPQK YGPDAFFNFP GKSAAAIALP PIAKWPYQNG FTFHTWLRMD 240 PVNNINVDKD KPYLYCFRTS KGLGYSAHFV GGCLIVTSIK SKGKGFQHCV KFDFKPQKWY 300 MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET ADANRVFCGQ 360 MTAVYLFSEA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL AEHHKLLLYD GKLSSAIAFT 420 YNPRATDAQL CLESSPKDNP SIFVHSPHAL MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF 480 AQLDYRQYLS DEIDLTICST LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV 540 SRAVLELCLA FSKYLSNLQN GMPLLKQLCD HVLLNPAIWI HTPAKVQLML YTYLSTEFIG 600 TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE MLSLRAFLLM 660 FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL VALMSEHPNS MIPAFDQRNG 720 LRVIYKLLAS KSEGIRVQAL KAMGYFLKHL APKRKAEVML GHGLFSLLAE RLMLQTNLIT 780 MTTYNVLFEI LIEQIGTQVI HKQHPDPDSS VKIQNPQILK VIATLLRNSP QCPESMEVRR 840 AFLSDMIKLF NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH 900 AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREQQ GKVDEEIGLC SSTSVQAASG 960 IRRDINVSVG SQQPDTKDSP VCPHFTTNGN ENSSIEKTSS LESASNIELQ TTNTSYEEMK 1020 AEQENQELPD EGTLEETLTN ETRNADDLEV SSDIIEAVAI SSNSFITTGK DSMTVSEVTA 1080 SISSPSEEDA SEMPEFLDKS IVEEEEDDDY VELKVEGSPT EEANLPTELQ DNSLSPAASE 1140 AGEKLDMFGN DDKLIFQEGK PVTEKQTDTE TQDSKDSGIQ TMTASGSSAM SPETTVSQIA 1200 VESDLGQMLE EGKKATNLTR ETKLINDCHG SVSEASSEQK IAKLDVSNVA TDTERLELKA 1260 SPNVEAPQPH RHVLEISRQH EQPGQGIAPD AVNGQRRDSR STVFRIPEFN WSQMHQRLLT 1320 DLLFSIETDI QMWRSHSTKT VMDFVNSSDN VIFVHNTIHL ISQVMDNMVM ACGGILPLLS 1380 AATSATHELE NIEPTQGLSI EASVTFLQRL ISLVDVLIFA SSLGFTEIEA EKSMSSGGIL 1440 RQCLRLVCAV AVRNCLECQQ HSQLKTRGDK ALKPMHSLIP LGKSAAKSPV DIVTGGISPV 1500 RDLDRLLQDM DINRLRAVVF RDIEDSKQAQ FLALAVVYFI SVLMVSKYRD ILEPQNERHS 1560 QSCTETGSEN ENVSLSEITP AAFSTLTTAS VEESESTSSA RRRDSGIGEE TATGLGSHVE 1620 VTPHTAPPGV SAGPDAISEV LSTLSLEVNK SPETKNDRGN DLDTKATPSV SVSKNVNVKD 1680 ILRSLVNIPA DGVTVDPALL PPACLGALGD LSVEQPVQFR SFDRSVIVAA KKSAVSPSTF 1740 NTSIPTNAVS VVSSVDSAQA SDMGGESPGS RSSNAKLPSV PTVDSVSQDP VSNMSITERL 1800 EHALEKAAPL LREIFVDFAP FLSRTLLGSH GQELLIEGTS LVCMKSSSSV VELVMLLCSQ 1860 EWQNSIQKNA GLAFIELVNE GRLLSQTMKD HLVRVANEAE FILSRQRAED IHRHAEFESL 1920 CAQYSADKRE DEKMCDHLIR AAKYRDHVTA TQLIQKIINI LTDKHGAWGN SAVSRPLEFW 1980 RLDYWEDDLR RRRRFVRNPL GSTHPEATLK TAVEHATDED ILAKGKQSIR SQALGNQNSE 2040 NEILLEGDDD TLSSVDEKDL ENLAGPVSLS TPAQLVAPSV VVKGTLSVTS SELYFEVDEE 2100 DPNFKKIDPK ILAYTEGLHG KWLFTEIRSI FSRRYLLQNT ALEIFMANRV AVMFNFPDPA 2160 TVKKVVNYLP RVGVGTSFGL PQTRRISLAS PRQLFKASNM TQRWQHREIS NFEYLMFLNT 2220 IAGRSYNDLN QYPVFPWVIT NYESEELDLT LPTNFRDLSK PIGALNPKRA AFFAERYESW 2280 EDDQVPKFHY GTHYSTASFV LAWLLRIEPF TTYFLNLQGG KFDHADRTFS SISRAWRNSQ 2340 RDTSDIKELI PEFYYLPEMF VNFNNYNLGV MDDGTVVSDV ELPPWAKTSE EFVHINRLAL 2400 ESEFVSCQLH QWIDLIFGYK QQGPEAVRAL NVFYYLTYEG AVNLNSITDP VLREAVEAQI 2460 RSFGQTPSQL LIEPHPPRGS AMQVSPLMFT DKAQQDVIMV LKFPSNSPVT HVAANTQPGL 2520 ATPAVITVTA NRLFAVNKWH NLPAHQGAVQ DQPYQLPVEI DPLIASNTGM HRRQITDLLD 2580 QSIQVHSQCF VITSDNRYIL VCGFWDKSFR VYSTDTGRLI QVVFGHWDVV TCLARSESYI 2640 GGNCYILSGS RDATLLLWYW NGKCSGIGDN PGETAAPRAI LTGHDYEVTC AAVCAELGLV 2700 LSGSQEGPCL IHSMNGDLLR TLEGPENCLK PKLIQASREG HCVIFYENGL FCTFSVNGKL 2760 QATMETDDNI RAIQLSRDGQ YLLTGGDRGV VVVRQVSDLK QLFAYPGCDA GIRAMALSYD 2820 QRCIISGMAS GSIVLFYNDF NRWHHEYQTR Y 2851 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:Compara. GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |