CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001937
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hemoglobin subunit beta-1 
Protein Synonyms/Alias
 Beta-1-globin; Hemoglobin beta chain, major-form; Hemoglobin beta-1 chain 
Gene Name
 Hbb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
9VHLTDAEKAAVNGLWacetylation[1]
18AVNGLWGKVNPDDVGacetylation[1]
18AVNGLWGKVNPDDVGubiquitination[2]
60SAIMGNPKVKAHGKKacetylation[1]
66PKVKAHGKKVINAFNacetylation[1]
67KVKAHGKKVINAFNDacetylation[1]
67KVKAHGKKVINAFNDubiquitination[2]
77NAFNDGLKHLDNLKGacetylation[1]
77NAFNDGLKHLDNLKGubiquitination[2]
83LKHLDNLKGTFAHLSacetylation[1]
96LSELHCDKLHVDPENacetylation[1]
133CAQAAFQKVVAGVASacetylation[1]
145VASALAHKYH*****acetylation[1]
145VASALAHKYH*****ubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 Involved in oxygen transport from the lung to the various peripheral tissues. 
Sequence Annotation
 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 MOD_RES 45 45 Phosphoserine (By similarity).  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 147 AA 
Protein Sequence
MVHLTDAEKA AVNGLWGKVN PDDVGGEALG RLLVVYPWTQ RYFDSFGDLS SASAIMGNPK 60
VKAHGKKVIN AFNDGLKHLD NLKGTFAHLS ELHCDKLHVD PENFRLLGNM IVIVLGHHLG 120
KEFTPCAQAA FQKVVAGVAS ALAHKYH 147 
Gene Ontology
 GO:0005833; C:hemoglobin complex; IDA:RGD.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0031721; F:hemoglobin alpha binding; IDA:RGD.
 GO:0031722; F:hemoglobin beta binding; IDA:RGD.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0006749; P:glutathione metabolic process; IDA:RGD.
 GO:0015671; P:oxygen transport; IDA:RGD.
 GO:0051291; P:protein heterooligomerization; IDA:RGD. 
Interpro
 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 
Pfam
 PF00042; Globin 
SMART
  
PROSITE
 PS01033; GLOBIN 
PRINTS
 PR00814; BETAHAEM.