CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022328
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingomyelin phosphodiesterase 4 
Protein Synonyms/Alias
 Neutral sphingomyelinase 3; nSMase-3; nSMase3; Neutral sphingomyelinase III 
Gene Name
 SMPD4 
Gene Synonyms/Alias
 KIAA1418 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106KLQAEDYKFDFPVSYubiquitination[1]
238LHHTSLLKRHISHQTubiquitination[1]
385PWRYAPDKQAPGSDSubiquitination[1]
400QPRCVSEKWAPFVQEubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. 
Sequence Annotation
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 669 669 Phosphothreonine.  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase; Magnesium; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 827 AA 
Protein Sequence
MAFPHLQQPS FLLASLKADS INKPFAQQCQ DLVKVIEDFP AKELHTIFPW LVESIFGSLD 60
GVLVGWNLRC LQGRVNPVEY SIVMEFLDPG GPMMKLVYKL QAEDYKFDFP VSYLPGPVKA 120
SIQECILPDS PLYHNKVQFT PTGGLGLNLA LNPFEYYIFF FALSLITQKP LPVSLHVRTS 180
DCAYFILVDR YLSWFLPTEG SVPPPLSSSP GGTSPSPPPR TPAIPFASYG LHHTSLLKRH 240
ISHQTSVNAD PASHEIWRSE TLLQVFVEMW LHHYSLEMYQ KMQSPHAKES FTPTEEHVLV 300
VRLLLKHLHA FANSLKPEQA SPSAHSHATS PLEEFKRAAV PRFVQQKLYL FLQHCFGHWP 360
LDASFRAVLE MWLSYLQPWR YAPDKQAPGS DSQPRCVSEK WAPFVQENLL MYTKLFVGFL 420
NRALRTDLVS PKHALMVFRV AKVFAQPNLA EMIQKGEQLF LEPELVIPHR QHRLFTAPTF 480
TGSFLSPWPP AVTDASFKVK SHVYSLEGQD CKYTPMFGPE ARTLVLRLAQ LITQAKHTAK 540
SISDQCAESP AGHSFLSWLG FSSMDTNGSY TANDLDEMGQ DSVRKTDEYL EKALEYLRQI 600
FRLSEAQLRQ FTLALGTTQD ENGKKQLPDC IVGEDGLILT PLGRYQIING LRRFEIEYQG 660
DPELQPIRSY EIASLVRTLF RLSSAINHRF AGQMAALCSR DDFLGSFCRY HLTEPGLASR 720
HLLSPVGRRQ VAGHTRGPRL SLRFLGSYRT LVSLLLAFFV ASLFCVGPLP CTLLLTLGYV 780
LYASAMTLLT ERGKLHQP 798 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:HGNC.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005802; C:trans-Golgi network; IDA:HGNC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004767; F:sphingomyelin phosphodiesterase activity; TAS:Reactome.
 GO:0050290; F:sphingomyelin phosphodiesterase D activity; IDA:HGNC.
 GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.
 GO:0046513; P:ceramide biosynthetic process; IDA:BHF-UCL.
 GO:0046475; P:glycerophospholipid catabolic process; IDA:BHF-UCL.
 GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.
 GO:0006685; P:sphingomyelin catabolic process; IDA:HGNC. 
Interpro
 IPR024129; Sphingomy_SMPD4. 
Pfam
  
SMART
  
PROSITE
  
PRINTS