UniProt Accession

 HINFP_HUMAN; Q9BQA5; B3KPH6; B4DWB4; E9PQF4; Q96E65; Q9Y4M7 

Genbank Protein ID

 AK056362; AK301452; AP002956; AP003391; CH471065; BC001073; BC001945; BC012856; BC017234; AL080201 

Genbank Nucleotide ID

 BAG51688.1; BAG62976.1; EAW67461.1; AAH01073.1; AAH01945.1; AAH12856.1; AAH17234.1; CAB45773.1 

Protein Name

 Histone H4 transcription factor 

Protein Synonyms/Alias

 Histone nuclear factor P; HiNF-P; MBD2-interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein 

Gene Name

 HINFP 

Gene Synonyms/Alias

 MIZF; ZNF743 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
330	ARSLCSIKSHYRKVH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. 

Sequence Annotation

 ZN_FING 15 39 C2H2-type 1.
 ZN_FING 129 153 C2H2-type 2.
 ZN_FING 169 193 C2H2-type 3.
 ZN_FING 199 221 C2H2-type 4; degenerate.
 ZN_FING 229 251 C2H2-type 5.
 ZN_FING 255 278 C2H2-type 6.
 ZN_FING 284 306 C2H2-type 7.
 ZN_FING 312 337 C2H2-type 8.
 ZN_FING 345 368 C2H2-type 9.
 REGION 373 517 Interaction with NPAT.
 REGION 374 407 Required for activation of histone H4  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 517 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000077; P:DNA damage checkpoint; IMP:UniProtKB.
 GO:0006281; P:DNA repair; IMP:UniProtKB.
 GO:0045184; P:establishment of protein localization; IMP:UniProtKB.
 GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
 GO:0045445; P:myoblast differentiation; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS