UniProt Accession

 FOXJ2_HUMAN; Q9P0K8; A0AVK4; B2RMP3; Q96PS9; Q9NSN5 

Genbank Protein ID

 AF155132; AF155133; BC126396; BC136305; AL161978 

Genbank Nucleotide ID

 AAF65927.1; AAK49016.1; AAI26397.1; AAI36306.1; CAB82315.1 

Protein Name

 Forkhead box protein J2 

Protein Synonyms/Alias

 Fork head homologous X 

Gene Name

 FOXJ2 

Gene Synonyms/Alias

 FHX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
26	TLRATIEKLGSASQA	ubiquitination	[1, 2]
260	WSFRNLYKSMLEKSS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S. 

Sequence Annotation

 DNA_BIND 66 143 Fork-head.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 3 3 Phosphoserine.
 MOD_RES 161 161 Phosphoserine.
 MOD_RES 172 172 Phosphoserine.  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 574 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0008301; F:DNA binding, bending; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0019904; F:protein domain specific binding; IBA:RefGenome.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0008134; F:transcription factor binding; IBA:RefGenome.
 GO:0009790; P:embryo development; IBA:RefGenome.
 GO:0048513; P:organ development; IBA:RefGenome.
 GO:0007389; P:pattern specification process; IBA:RefGenome.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0009888; P:tissue development; IBA:RefGenome. 

Interpro

 IPR001766; TF_fork_head.
 IPR018122; TF_fork_head_CS.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00250; Fork_head 

SMART

 SM00339; FH 

PROSITE

 PS00657; FORK_HEAD_1
 PS00658; FORK_HEAD_2
 PS50039; FORK_HEAD_3 

PRINTS

 PR00053; FORKHEAD.