CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014120
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM208B 
Protein Synonyms/Alias
  
Gene Name
 FAM208B 
Gene Synonyms/Alias
 C10orf18; KIAA2006 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24LMSPWKGKLIVQDRMubiquitination[1]
75LPEAAFRKQNYLEEKubiquitination[1]
165SPLSTGVKDLKVEDDubiquitination[1]
192NCALLETKKSLPEERubiquitination[1]
193CALLETKKSLPEERIubiquitination[1]
207IHPNTLVKRHFQELYubiquitination[1]
694EAATPVGKVMPFRHQubiquitination[2, 3, 4]
717PPDDPVVKPKDRPPSubiquitination[5]
768YTNNPLEKTVVRALHubiquitination[2, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 MOD_RES 19 19 Phosphoserine.
 MOD_RES 384 384 Phosphoserine.
 MOD_RES 1087 1087 Phosphoserine.
 MOD_RES 2009 2009 Phosphoserine.
 MOD_RES 2037 2037 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2430 AA 
Protein Sequence
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP QELDFKYVMK 60
VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR QGENIDKLTE CIKNKQLAII 120
KCLEDRGFFI LLTSSALLSE PDFGGKQMGL HGLHLFRSPL STGVKDLKVE DDISMKVIPI 180
LSTLNCALLE TKKSLPEERI HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP 240
SGFDLIPPAE KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS 300
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK RKASMPHMVQ 360
SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK RGAEVLTAQF VQKTKLDRKN 420
QEAPISKDVP VPTNAKRARK QEKSPVKTVP RAKPPVKKSP QKQRVNIVKG NENPRNRKQL 480
QPVKGETASK LQSEISRGCQ EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL 540
ALSSATSSTP VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS 600
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV SVEHSYALLL 660
TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH QPGLLLQQKP PDDPVVKPKD 720
RPPSARVKKS SCSRIVLSCD DSVKITFKCE TEYAFSLDSK YTNNPLEKTV VRALHGPWNT 780
DLPDNVEEVK LLLHMWVALF YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE 840
SLGLEKCSAD SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR 900
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV PSEEEIVQPL 960
DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE NKVDILDAAV QTKTGTLQDL 1020
IQHGSPINNE CHPSLERKDD NMGCAVINPE PITLTFEKNA HVPIQTEGVN TADERTTFKK 1080
ELIKQVSPAA SLRHPVSTSE NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS 1140
LQKETPLPVS LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE 1200
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM NLEAFDSVFI 1260
KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA GEIEQFEEAP FSNLELQDVA 1320
EEIGEPEEVA LTESREVSSA DNVSVYPSVS EEPVENKERK GDNLQPVTLI LSKENCTLEI 1380
AEEINVTSDF PFDSVIEEVS PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ 1440
CESEDLGITE KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT 1500
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN PLQPVSIENR 1560
NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI VNVSVKQQTS PKSSQNHLFP 1620
GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC MCSVVPTLCS SSDNATLTHY VRPINAEPVF 1680
QAQEIPAGRM ASLLKNGEPE AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE 1740
TKELLNVGVS SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG 1800
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT LRGSYTRKKD 1860
VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA AVKKEEKCVP PYVQIRDLHG 1920
ILRTYANFSI TKELKDTMRT SHGLRRHPSF SANCGLPSSW TSTWQVADDL TQNTLDLEYL 1980
RFAHKLKQTI KNGDSQHSAS SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL 2040
VTVVESDPRP QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST 2100
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP FPGRSASYED 2160
IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR TKNLLRKGGH TEIEPQHFCQ 2220
AFHRENDTLI IIIRNEDISS HLHQIPSLLK LKHFPSVIFA GVDSPGDVLD HTYQELFRAG 2280
GFVISDDKIL EAVTLVQLKE IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN 2340
IMLKSFQSAN IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV 2400
FENSGILVTD VNNFIENIEK IAAPFRSSYW 2430 
Gene Ontology
  
Interpro
 IPR022168; DUF3699.
 IPR022188; DUF3715. 
Pfam
 PF12480; DUF3699
 PF12509; DUF3715 
SMART
  
PROSITE
  
PRINTS