UniProt Accession

 RAB1B_HUMAN; Q9H0U4; A8K7S1 

Genbank Protein ID

 AF092437; AL136635; AK292086; AK315333; BC071169 

Genbank Nucleotide ID

 AAP97212.1; CAB66570.1; BAF84775.1; BAG37733.1; AAH71169.1 

Protein Name

 Ras-related protein Rab-1B 

Protein Synonyms/Alias

  

Gene Name

 RAB1B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
55	RTIELDGKTIKLQIW	ubiquitination	[1]
116	YASENVNKLLVGNKS	ubiquitination	[1, 2]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. 

Sequence Annotation

 NP_BIND 15 22 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 121 124 GTP (By similarity).
 REGION 64 83 Switch 2 region; required for interaction
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 76 76 O-(2-cholinephosphoryl)serine; by
 MOD_RES 77 77 O-AMP-tyrosine; by Legionella DrrA.
 MOD_RES 201 201 Cysteine methyl ester (Potential).
 LIPID 200 200 S-geranylgeranyl cysteine.
 LIPID 201 201 S-geranylgeranyl cysteine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Phosphoprotein; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 201 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:LIFEdb.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.