CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029440
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 PDPR 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60PSEIISPKKVAELHHubiquitination[1]
61SEIISPKKVAELHHLubiquitination[2]
210GGFEKNPKPIFTEGKubiquitination[2]
345MPLMYDLKVPRWDFQubiquitination[1]
403EQSKTFYKPDWFDIVubiquitination[1]
645ESRVKLEKGMDFIGRubiquitination[2]
659RDALLQQKQNGVYKRacetylation[3]
659RDALLQQKQNGVYKRubiquitination[2]
698RNGQYVGKTTSSAYSubiquitination[2]
765VASLFTQKRRKDDMEubiquitination[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 779 AA 
Protein Sequence
MADYSNKLYY QLEQETGIQT GYTRTGSIFL AQTQDRLISL KRINAGLNVI GIPSEIISPK 60
KVAELHHLLN VHDLVGAMHV PEDAVVSSAD VALALASAAS QNGVQIYDRT SVLHVMVKKG 120
QVTGVETDKG QIECQYFVNC AGQWAYELGL SNEEPVSIPL HACEHFYLLT RPLETPLQSS 180
TPTIVDADGR IYIRNWQGGI LSGGFEKNPK PIFTEGKNQL EIQNLQEDWD HFEPLLSSLL 240
RRMPELETLE IMKLVNCPET FTPDMRCIMG ESPAVQGYFV LAGMNSAGLS FGGGAGKYLA 300
EWMVHGYPSE NVWELDLKRF GALQSSRTFL RHRVMEVMPL MYDLKVPRWD FQTGRQLRTS 360
PLYDRLDAQG ARWMEKHGFE RPKYFVPPDK DLLALEQSKT FYKPDWFDIV ESEVKCCKEA 420
VCVIDMSSFT KFEITSTGDQ ALEVLQYLFS NDLDVPVGHI VHTGMLNEGG GYENDCSIAR 480
LNKRSFFMIS PTDQQVHCWA WLKKHMPKDS NLLLEDVTWK YTALNLIGPR AVDVLSELSY 540
APMTPDHFPS LFCKEMSVGY ANGIRVMSMT HTGEPGFMLY IPIEYALHVY NEVMSVGQKY 600
GIRNAGYYAL RSLRIEKFFA FWGQDINNLT TPLECGRESR VKLEKGMDFI GRDALLQQKQ 660
NGVYKRLTMF ILDDHDSDLD LWPWWGEPIY RNGQYVGKTT SSAYSYSLER HVCLGFVHNF 720
SEDTGEEQVV TADFINRGEY EIDIAGYRFQ AKAKLYPVAS LFTQKRRKDD MELSDLHGK 779 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0006546; P:glycine catabolic process; IEA:InterPro. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01266; DAO
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS