UniProt Accession

 MCK1_YEAST; P21965; D6W0N8 

Genbank Protein ID

 X55054; M55984; Z46259; Z71583; Z71582; BK006947 

Genbank Nucleotide ID

 CAA38895.1; AAA34764.1; CAA86388.1; CAA96236.1; CAA96235.1; DAA10254.1 

Protein Name

 Protein kinase MCK1 

Protein Synonyms/Alias

 Meiosis and centromere regulatory kinase 

Gene Name

 MCK1 

Gene Synonyms/Alias

 YPK1; YNL307C; N0392 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
36	NTRRMLVKEYRKIGR	acetylation	[1]
133	INRYVTNKLEMPLKH	acetylation	[1]
166	GVCHRDIKPSNVLVD	ubiquitination	[2]
291	SSQQRFEKYFGHSGP	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 May be an autophosphorylating tyrosine kinase, a bifunctional (serine/tyrosine-specific) protein kinase, or a serine kinase that is a substrate for an associated tyrosine kinase. MCK1 is a transcriptional activator of IME1, it stimulates spore maturation, and play a positive regulatory role in both mitotic centromere function and activation of early meiotic gene expression. 

Sequence Annotation

 DOMAIN 35 327 Protein kinase.
 NP_BIND 41 49 ATP (By similarity).
 ACT_SITE 164 164 Proton acceptor (By similarity).
 BINDING 68 68 ATP (By similarity).
 MOD_RES 198 198 Phosphoserine.
 MOD_RES 199 199 Phosphotyrosine.
 MOD_RES 202 202 Phosphoserine.  

Keyword

 ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 375 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:SGD.
 GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IDA:SGD.
 GO:0030437; P:ascospore formation; IMP:SGD.
 GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:SGD.
 GO:0007126; P:meiosis; IMP:SGD.
 GO:0000070; P:mitotic sister chromatid segregation; IGI:SGD.
 GO:1902002; P:protein phosphorylation involved in cellular protein catabolic process; IMP:SGD. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00220; S_TKc 

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS