UniProt Accession

 SEM5A_HUMAN; Q13591; D3DTC6; O60408; Q1RLL9 

Genbank Protein ID

 U52840; AC004615; AC022446; AC027336; AC091906; CH471102; CH471102; BC115696 

Genbank Nucleotide ID

 AAC09473.1; AAC14668.1; EAX08078.1; EAX08079.1; AAI15697.1 

Protein Name

 Semaphorin-5A 

Protein Synonyms/Alias

 Semaphorin-F; Sema F 

Gene Name

 SEMA5A 

Gene Synonyms/Alias

 SEMAF 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1035	YDSVEAIKAFNKNNL	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. 

Sequence Annotation

 DOMAIN 35 484 Sema.
 DOMAIN 540 593 TSP type-1 1.
 DOMAIN 595 651 TSP type-1 2.
 DOMAIN 653 702 TSP type-1 3.
 DOMAIN 707 765 TSP type-1 4.
 DOMAIN 784 839 TSP type-1 5.
 DOMAIN 841 896 TSP type-1 6.
 DOMAIN 897 944 TSP type-1 7.
 CARBOHYD 142 142 N-linked (GlcNAc...) (Potential).
 CARBOHYD 168 168 N-linked (GlcNAc...) (Potential).
 CARBOHYD 227 227 N-linked (GlcNAc...) (Potential).
 CARBOHYD 277 277 N-linked (GlcNAc...) (Potential).
 CARBOHYD 323 323 N-linked (GlcNAc...) (Potential).
 CARBOHYD 367 367 N-linked (GlcNAc...) (Potential).
 CARBOHYD 437 437 N-linked (GlcNAc...) (Potential).
 CARBOHYD 536 536 N-linked (GlcNAc...) (Potential).
 CARBOHYD 591 591 N-linked (GlcNAc...) (Potential).
 CARBOHYD 717 717 N-linked (GlcNAc...) (Potential).
 CARBOHYD 933 933 N-linked (GlcNAc...) (Potential).
 DISULFID 104 114 By similarity.
 DISULFID 131 140 By similarity.
 DISULFID 254 357 By similarity.
 DISULFID 278 320 By similarity.
 DISULFID 487 504 By similarity.
 DISULFID 496 513 By similarity.
 DISULFID 607 644 By similarity.
 DISULFID 611 650 By similarity.
 DISULFID 622 634 By similarity.
 DISULFID 665 696 By similarity.
 DISULFID 669 701 By similarity.
 DISULFID 680 686 By similarity.
 DISULFID 796 833 By similarity.
 DISULFID 800 838 By similarity.
 DISULFID 811 823 By similarity.
 DISULFID 853 890 By similarity.
 DISULFID 857 895 By similarity.
 DISULFID 868 880 By similarity.  

Keyword

 Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1074 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0008046; F:axon guidance receptor activity; IEA:Compara.
 GO:0007411; P:axon guidance; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0001569; P:patterning of blood vessels; IEA:Compara. 

Interpro

 IPR003659; Plexin-like.
 IPR016201; Plexin-like_fold.
 IPR002165; Plexin_repeat.
 IPR027231; Semaphorin.
 IPR001627; Semaphorin/CD100_Ag.
 IPR000884; Thrombospondin_1_rpt.
 IPR015943; WD40/YVTN_repeat-like_dom. 

Pfam

 PF01437; PSI
 PF01403; Sema
 PF00090; TSP_1 

SMART

 SM00423; PSI
 SM00630; Sema
 SM00209; TSP1 

PROSITE

 PS51004; SEMA
 PS50092; TSP1 

PRINTS