UniProt Accession

 SUMO2_MOUSE; P61957; A2A9X2; P55855; Q542L8 

Genbank Protein ID

 L79948; AK012619; AK085238; AK132213; AK160404; AK167308; AL645470; BC017522; BC083326; BC095930 

Genbank Nucleotide ID

 AAL40136.1; BAB28360.1; BAC39397.1; BAE21037.1; BAE35772.1; BAE39412.1; CAM23014.1; AAH17522.1; AAH83326.1; AAH95930.1 

Protein Name

 Small ubiquitin-related modifier 2 

Protein Synonyms/Alias

 SUMO-2; SMT3 homolog 2; Sentrin-2; Ubiquitin-like protein SMT3A; Smt3A 

Gene Name

 Sumo2 

Gene Synonyms/Alias

 Smt3a; Smt3h2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
11	EKPKEGVKTENNDHI	ubiquitination	[1]
21	NNDHINLKVAGQDGS	ubiquitination	[1]
33	DGSVVQFKIKRHTPL	ubiquitination	[1]
45	TPLSKLMKAYCERQG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). 

Sequence Annotation

 DOMAIN 16 95 Ubiquitin-like.
 CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 11 11 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 93 93 Glycyl lysine isopeptide (Gly-Lys)  

Keyword

 Complete proteome; Isopeptide bond; Nucleus; Reference proteome; Ubl conjugation; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 95 AA 

Protein Sequence

Gene Ontology

 GO:0016605; C:PML body; ISS:UniProtKB.
 GO:0019789; F:SUMO ligase activity; IDA:MGI.
 GO:0031625; F:ubiquitin protein ligase binding; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.
 GO:0016925; P:protein sumoylation; ISS:UniProtKB. 

Interpro

 IPR022617; SUMO.
 IPR027218; SUMO_chordates.
 IPR000626; Ubiquitin.
 IPR019955; Ubiquitin_supergroup. 

Pfam

 PF11976; Rad60-SLD 

SMART

 SM00213; UBQ 

PROSITE

 PS50053; UBIQUITIN_2 

PRINTS