UniProt Accession

 VASN_HUMAN; Q6EMK4; Q6UXL4; Q6UXL5; Q96CX1 

Genbank Protein ID

 AY166584; AY358298; AY358299; BC013767; BC068575 

Genbank Nucleotide ID

 AAO27704.1; AAQ88665.1; AAQ88666.1; AAH13767.1; AAH68575.1 

Protein Name

 Vasorin 

Protein Synonyms/Alias

 Protein slit-like 2 

Gene Name

 VASN 

Gene Synonyms/Alias

 SLITL2; UNQ314/PRO357/PRO1282 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
612	MAAAAQDKGQVGPGA	ubiquitination	[1, 2, 3]
628	PLELEGVKVPLEPGP	ubiquitination	[1, 2, 3, 4]
670	LQSPLHAKPYI****	ubiquitination	[3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 

Functional Description

 May act as an inhibitor of TGF-beta signaling. 

Sequence Annotation

 DOMAIN 24 51 LRRNT.
 REPEAT 52 74 LRR 1.
 REPEAT 77 98 LRR 2.
 REPEAT 101 122 LRR 3.
 REPEAT 125 146 LRR 4.
 REPEAT 149 170 LRR 5.
 REPEAT 171 191 LRR 6.
 REPEAT 193 214 LRR 7.
 REPEAT 217 238 LRR 8.
 REPEAT 240 262 LRR 9.
 REPEAT 265 287 LRR 10.
 DOMAIN 298 351 LRRCT.
 DOMAIN 405 442 EGF-like.
 DOMAIN 458 555 Fibronectin type-III.
 CARBOHYD 101 101 N-linked (GlcNAc...).
 CARBOHYD 117 117 N-linked (GlcNAc...) (complex).
 CARBOHYD 273 273 N-linked (GlcNAc...).
 CARBOHYD 500 500 N-linked (GlcNAc...) (Potential).
 CARBOHYD 528 528 N-linked (GlcNAc...) (Potential).
 DISULFID 409 420 By similarity.
 DISULFID 414 430 By similarity.
 DISULFID 432 441 By similarity.  

Keyword

 Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Leucine-rich repeat; Membrane; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 673 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 

Interpro

 IPR000483; Cys-rich_flank_reg_C.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR003961; Fibronectin_type3.
 IPR013783; Ig-like_fold.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 

Pfam

 PF00560; LRR_1
 PF01462; LRRNT 

SMART

 SM00181; EGF
 SM00060; FN3
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 

PROSITE

 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS50853; FN3
 PS51450; LRR 

PRINTS