UniProt Accession

 YPR1_YEAST; Q12458; D6VSZ9 

Genbank Protein ID

 X80642; U28373; BK006938 

Genbank Nucleotide ID

 CAA56686.1; AAB64804.1; DAA12209.1 

Protein Name

 Putative reductase 1 

Protein Synonyms/Alias

  

Gene Name

 YPR1 

Gene Synonyms/Alias

 YDR368W; D9481.8 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
44	HSVIAALKAGYRHID	acetylation	[1]
118	MHWPVPLKTDRVTDG	ubiquitination	[2]
264	RGYVVLAKSVNPERI	acetylation	[1]
276	ERIVSNFKIFTLPED	acetylation	[1]
286	TLPEDDFKTISNLSK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 NP_BIND 220 274 NADP (By similarity).
 ACT_SITE 56 56 Proton donor (By similarity).
 BINDING 112 112 Substrate (By similarity).
 MOD_RES 172 172 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; NADP; Oxidoreductase; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 312 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:SGD.
 GO:0004090; F:carbonyl reductase (NADPH) activity; IDA:SGD.
 GO:0047935; F:glucose 1-dehydrogenase (NADP+) activity; IDA:SGD.
 GO:0019568; P:arabinose catabolic process; IDA:SGD.
 GO:0034599; P:cellular response to oxidative stress; IGI:SGD.
 GO:0042843; P:D-xylose catabolic process; IDA:SGD. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.