CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013411
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytadherence high molecular weight protein 1 
Protein Synonyms/Alias
 Cytadherence accessory protein 1 
Gene Name
 hmw1 
Gene Synonyms/Alias
 MPN_447; MP394 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
5***MKKSKEAVFEDKacetylation[1]
820KDLSVYQKDELLRSLacetylation[1]
873KNIQITLKELKAVYKacetylation[1]
876QITLKELKAVYKLCSacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity). 
Sequence Annotation
  
Keyword
 Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytadherence; Direct protein sequencing; Membrane; Phosphoprotein; Reference proteome; Virulence. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1018 AA 
Protein Sequence
MKKSKEAVFE DKDYTEENPE QIFGNLYDGK LTVQDGKVKI AYDGDGNGYY IAFNSETGVY 60
YDPYGDTEYD ISVLFDANGN SFVFADAPTV EVLAGEQEQT EAEPDYLQYV GNEAYGYYDE 120
AGEWVWSGYF EGDQWISTLP QTEAEEKQFG FEDNIETTPT ASEDFGLEAD VPAPEVAEPS 180
YEVQPEVAAE PVYDVQPEVA VEPVGETTAT VEPQAVEIQP EVVVEPIVES QLEQPVEVQA 240
EMVQPEVAVE PQLEVSLDPI GETAPILEQV EPQAVQTQPE IPAEQSAVEL QPEPVAEVQS 300
EMVQPEAAAE PVTEAQQTEP TPVVETIAEI TPQVVTEPVV AVVEHQPEAV AEPLPVEPAV 360
AGVSELIPTE QVQPEVVVES TPVAEVQSEM VQPEVAVEPI VEPQPEQPVE VQPEVITTPE 420
VASVLEVQPE NPVVEVEQVV EPQPETPVEV QPEPVVETVQ EAVAEPTQVV EPQPQAAPQP 480
AVYEWNLTPE AAPVEQPEVI PVTVVESQAT ATAEPQPAVA PVADMDYVLH LTDTVKNQPQ 540
TAPVQPTTPI KIEVAESTPT VTTSPVEPTI APPLFEIELN NTTSSDLPLV EVVDFKHNQH 600
GAVGTHSFDD FTPPEVGMES KTHCHSNSEV VWRVSEPKTV PVPPAVSSIN IQTVNRVVEP 660
TISTPTTPVV ESAPAIEIFV DTPPVETKEA SSNVDVVQQP VKPLMPVMVE QLRTTELQPT 720
TEINLFANSD INSIIAELKQ GRSNPAINFD DIFKMSSYQM VVKKSFVQIS DFITNSKTDI 780
TNRFLLIKKE LQAELTRLIE ENEQLKAEFL NAKDLSVYQK DELLRSLSND FTIAHRPSDS 840
YEQLQKSGEL VRNIQKAILE NESKIKNIQI TLKELKAVYK LCSDTVLNGM AKLDSVLRFN 900
KKEKDPLLLN SMETLSSFET EPQAIIEDLL DFSSSFDKMS NEQLDEFVYQ NLDSGLNLDL 960
DGFDHQLSSM NIHGLEPLDP MKLDDFDFET LTPDKTSNLS SILDDELMEN GGDFNLDY 1018 
Gene Ontology
 GO:0033111; C:attachment organelle membrane; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0020035; P:cytoadherence to microvasculature, mediated by symbiont protein; IEA:UniProtKB-KW.
 GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. 
Interpro
 IPR022466; AGR_box.
 IPR021199; Cytadherence_HMW-1_N. 
Pfam
  
SMART
  
PROSITE
  
PRINTS