UniProt Accession

 RMD3_MOUSE; Q3UJU9; A9UN03; Q3U5Y8; Q3UB61; Q6P8M2; Q7TNF2 

Genbank Protein ID

 AK146299; AK151090; AK153369; AK153322; AL772264; BC055754; BC061186; BR000695 

Genbank Nucleotide ID

 BAE27056.1; BAE30103.1; BAE31937.1; BAE31902.1; CAM45949.1; AAH55754.1; AAH61186.1; FAA00420.1 

Protein Name

 Regulator of microtubule dynamics protein 3 

Protein Synonyms/Alias

 RMD-3; mRMD-3; Protein FAM82A2; Protein FAM82C 

Gene Name

 Rmdn3 

Gene Synonyms/Alias

 Fam82a2; Fam82c 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
306	KSYALNGKEEAEAAL	acetylation	[1]
306	KSYALNGKEEAEAAL	ubiquitination	[2]
434	KCYRELGKNSEARKW	acetylation	[1, 3]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). 

Sequence Annotation

 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 46 46 Phosphoserine.
 MOD_RES 50 50 Phosphoserine.
 MOD_RES 189 189 Phosphoserine.
 MOD_RES 212 212 Phosphoserine.  

Keyword

 Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Membrane; Microtubule; Mitochondrion; Mitochondrion outer membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 470 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB. 

Interpro

 IPR011990; TPR-like_helical. 

Pfam

  

SMART

  

PROSITE

  

PRINTS