UniProt Accession

 ZN776_HUMAN; Q68DI1; Q6ZS36; Q8N968 

Genbank Protein ID

 CR749390; AC003006; AK127764; AK095607 

Genbank Nucleotide ID

 CAH18239.1; BAC87119.1; BAC04588.1 

Protein Name

 Zinc finger protein 776 

Protein Synonyms/Alias

  

Gene Name

 ZNF776 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	AKDETPSKQTLSIQQ	ubiquitination	[1, 2]
122	GFGAYEKKLDDDANH	ubiquitination	[2]
134	ANHHQDQKQHIGEKS	ubiquitination	[2]
190	EDIHTSGKSNFETKH	ubiquitination	[2, 3]
196	GKSNFETKHGIPLQG	ubiquitination	[2, 3]
220	STIPFSNKHSLVLHQ	ubiquitination	[2]
243	YVCSDSGKFTSKSNS	ubiquitination	[2, 3]
360	CGKSFNHKCNLIQHQ	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be involved in transcriptional regulation (By similarity). 

Sequence Annotation

 DOMAIN 14 89 KRAB.
 ZN_FING 208 230 C2H2-type 1; degenerate.
 ZN_FING 236 258 C2H2-type 2; degenerate.
 ZN_FING 264 286 C2H2-type 3.
 ZN_FING 292 314 C2H2-type 4.
 ZN_FING 320 342 C2H2-type 5.
 ZN_FING 348 370 C2H2-type 6.
 ZN_FING 376 398 C2H2-type 7.
 ZN_FING 404 426 C2H2-type 8.
 ZN_FING 432 454 C2H2-type 9.
 ZN_FING 460 482 C2H2-type 10; degenerate.
 ZN_FING 488 510 C2H2-type 11.  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 518 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF01352; KRAB 

SMART

 SM00349; KRAB
 SM00355; ZnF_C2H2 

PROSITE

 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS