CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033237
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 TBC1 domain family member 15 
Protein Synonyms/Alias
  
Gene Name
 TBC1D15 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MVNTVSFKRKPHTNGubiquitination[1]
10NTVSFKRKPHTNGDAubiquitination[2]
91LCESPQDKRTLLVNCubiquitination[3]
101LLVNCQNKSLSQSFEubiquitination[3, 4]
121PAYGLIQKIKKDPYTubiquitination[1, 2, 3, 4]
123YGLIQKIKKDPYTATubiquitination[1, 3, 5, 6]
124GLIQKIKKDPYTATMubiquitination[1, 3, 5]
136ATMIGFSKVTNYIFDubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 278 AA 
Protein Sequence
MVNTVSFKRK PHTNGDAPSH RNGKSKWSFL FSLTDLKSIK QNKEGMGWSY LVFCLKDDVV 60
LPALHFHQGD SKLLIESLEK YVVLCESPQD KRTLLVNCQN KSLSQSFENL LDEPAYGLIQ 120
KIKKDPYTAT MIGFSKVTNY IFDSLRGSDP STHQRPPSEM ADFLSDAIPG LKINQQEEPG 180
FEVITRIDLG ERPVVQRREP VSLEEWTKNI DSEGRILNVD NMKQMIFRGG LSHALRKQAW 240
KFLLGYFPWD STKEERTQLQ KQKTDEYFRM KLQWKSIS 278 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR021935; DUF3548.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF12068; DUF3548 
SMART
  
PROSITE
 PS50086; TBC_RABGAP 
PRINTS