CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019881
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plastin-3 
Protein Synonyms/Alias
 T-plastin 
Gene Name
 Pls3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
297NNFSADIKDSKAYFHacetylation[1]
582GNLTEDDKHNNAKYAacetylation[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Actin-bundling protein (By similarity). 
Sequence Annotation
 DOMAIN 12 47 EF-hand 1.
 DOMAIN 52 87 EF-hand 2.
 DOMAIN 109 382 Actin-binding 1.
 DOMAIN 123 239 CH 1.
 DOMAIN 267 378 CH 2.
 DOMAIN 383 627 Actin-binding 2.
 DOMAIN 397 506 CH 3.
 DOMAIN 518 627 CH 4.
 MOD_RES 293 293 Phosphoserine (By similarity).
 MOD_RES 326 326 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphothreonine (By similarity).
 CROSSLNK 168 168 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Actin-binding; Calcium; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 630 AA 
Protein Sequence
MDEMATTQIS KDELDELKEA FAKVDLNSNG FICDYELHEL FKEANMPLPG YKVREIIQKL 60
MVDGDRNKDG KISFNEFVYI FQEVKSSDIA KTFRKAINRK EGICALGGTS ELSSEGTQHS 120
YSEEEKYAFV NWINKALEND PDCRHVIPMN PNTDDLFKAV GDGIVLCKMI NLSVPDTIDE 180
RAINKKKLTP FIIQENLNLA LNSASAIGCH VVNIGAEDLR AGKPHLVLGL LWQIIKIGLF 240
ADIELSRNEA LAALLRDGET LEELMKLSPE ELLLRWANFH LENSGWQKIN NFSADIKDSK 300
AYFHLLNQIA PKGQKEGEPR IDINMSGFNE TDDLKRAESM LQQADKLGCR QFVTPADVVS 360
GNPKLNLAFV ANLFNKYPAL TKPENQDIDW TLLEGETREE RTFRNWMNSL GVNPHVNHLY 420
ADLQDALVIL QLYERIKVPV DWSKVNKPPY PKLGANMKKL ENCNYAVELG KNPAKFSLVG 480
IGGQDLNDGN PTLTLAVVWQ LMRRYTLNVL EDLGEGQKAN DDIIVNWVNR TLSEAGKSTS 540
IQSFKDKTIS SSLAVVDLID AIQPGCINYD LVKSGNLTED DKHNNAKYAV SMARRIGARV 600
YALPEDLVEV KPKMVMTVFA CLMGRGMKRV 630 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF00307; CH
 PF13499; EF_hand_5 
SMART
 SM00033; CH
 SM00054; EFh 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS