UniProt Accession

 PP2AB_MOUSE; P62715; P11082 

Genbank Protein ID

 Z67746; BC058582 

Genbank Nucleotide ID

 CAA91559.1; AAH58582.1 

Protein Name

 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 

Protein Synonyms/Alias

 PP2A-beta 

Gene Name

 Ppp2cb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
8	MDDKAFTKELDQWVE	ubiquitination	[1]
21	VEQLNECKQLNENQV	ubiquitination	[1]
41	KAKEILTKESNVQEV	acetylation	[2, 3]
41	KAKEILTKESNVQEV	ubiquitination	[1]
74	ELFRIGGKSPDTNYL	ubiquitination	[1]
136	FYDECLRKYGNANVW	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. 

Sequence Annotation

 ACT_SITE 118 118 Proton donor (By similarity).
 METAL 57 57 Iron (By similarity).
 METAL 59 59 Iron (By similarity).
 METAL 85 85 Iron (By similarity).
 METAL 85 85 Manganese (By similarity).
 METAL 117 117 Manganese (By similarity).
 METAL 167 167 Manganese (By similarity).
 METAL 241 241 Manganese (By similarity).
 MOD_RES 307 307 Phosphotyrosine.
 MOD_RES 309 309 Leucine methyl ester (By similarity).  

Keyword

 Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 309 AA 

Protein Sequence

Gene Ontology

 GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; TAS:MGI.
 GO:0000159; C:protein phosphatase type 2A complex; IDA:MGI.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Compara.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0006470; P:protein dephosphorylation; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IMP:MGI.
 GO:0046677; P:response to antibiotic; IMP:MGI.
 GO:0034976; P:response to endoplasmic reticulum stress; IMP:MGI.
 GO:0042542; P:response to hydrogen peroxide; IMP:MGI. 

Interpro

 IPR004843; Metallo_PEstase_dom.
 IPR006186; Ser/Thr-sp_prot-phosphatase. 

Pfam

 PF00149; Metallophos 

SMART

 SM00156; PP2Ac 

PROSITE

 PS00125; SER_THR_PHOSPHATASE 

PRINTS

 PR00114; STPHPHTASE.