CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sec1 family domain-containing protein 1 
Protein Synonyms/Alias
 Syntaxin-binding protein 1-like 2 
Gene Name
 Scfd1 
Gene Synonyms/Alias
 Stxbp1l2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
321YDLTPVDKFWQKHKGubiquitination[1]
327DKFWQKHKGSPFPEVubiquitination[1]
392SLPELLEKKRLIDLHubiquitination[1]
491LSPLQYIKQWKAFAKubiquitination[1]
498KQWKAFAKMASTPASubiquitination[1]
512SYGNTTTKPMGLLSRubiquitination[1]
533QFVMEGVKNLVLKQQubiquitination[1]
538GVKNLVLKQQNLPVTubiquitination[1]
555LDNLMEMKSNPETDDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). 
Sequence Annotation
 MOD_RES 300 300 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MVGSKMAATA SIRERQTVAL KRMLNFNVPH VKNSTGEPVW KVLIYDRFGQ DIISPLLSVK 60
ELRDMGITLH LLLHSDRDPI PDVPAVYFVM PTEENIDRLC QDLRNQLYES YYLNFISAIS 120
RSKLEDIANA ALAASAVTQV AKVFDQYLNF ITLEDDMFVL CNQNKELVSY RAINRPDITD 180
TEMETVMDTI VDSLFCFFVT LGAVPIIRCS RGTAAEMVAV KLDKKLRENL RDARNSLFTG 240
DPLGTGQFSF QRPLLVLVDR NIDLATPLHH TWTYQALVHD VLDFHLNRVN LEESTGVENS 300
PAGARPKRKN KKSYDLTPVD KFWQKHKGSP FPEVAESVQQ ELESYRAQED EVKRLKSIMG 360
LEGEDEGAIS MLSDNTAKLT SAVSSLPELL EKKRLIDLHT NVATAVLEHI KARKLDVYFE 420
YEEKIMSKTT LDKSLLDVIS DPDAGTPEDK MRLFLIYYIS AQQAPSEVDL EQYKKALTDA 480
GCNLSPLQYI KQWKAFAKMA STPASYGNTT TKPMGLLSRV MNTGSQFVME GVKNLVLKQQ 540
NLPVTRILDN LMEMKSNPET DDYRYFDPKM LRSNDSSVPR NKSPFQEAIV FVVGGGNYIE 600
YQNLVDYIKA KQGKHILYGC SEIFNATQFI KQLSQLGQK 639 
Gene Ontology
 GO:0005801; C:cis-Golgi network; IEA:Compara.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IEA:Compara.
 GO:0005798; C:Golgi-associated vesicle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Compara.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:Compara.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS