CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045333
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho guanine nucleotide exchange factor 1 
Protein Synonyms/Alias
  
Gene Name
 ARHGEF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
288VPDFRHLKAEVDAEKubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 968 AA 
Protein Sequence
MEDFARGAAS PGPSRPGLVP VSIIGAEDED FENELETNSE EQNSQFQSLE QVKRRPAHLM 60
ALLQHVALQF EPGPLLCCLH ADMLGSLGPK EAKKAFLDFY HSFLEKTAVL RVPVPPNVAF 120
ELDRTRADLI SEDVQRRFVQ EVVQSQQVAV GRQLEDFRSK RLMGMTPWEQ ELAQLEAWVG 180
RDRASYEARE RHVAERLLMH LEEMQHTIST DEEKSAAVVN AIGLYMRHLG VRTKSGDKKS 240
GRNFFRKKVM GNRRSDEPAK TKKGLSSILD AARWNRGEPQ VPDFRHLKAE VDAEKPGATD 300
RKGGVGMPSR DRNIGAPGQD TPGVSLHPLS LDSPDREPGA DAPLELGDSS PQGPMSLESL 360
APPESTDEGA ETERLSGRLG RSESLRVSDR RRPSRGSLGA KGRGGGRSRS DVDMDPSSAT 420
AVLGPARRAT PEPGDEGEPG RSGLELEPEE PPGWRELVPP DTLHSLPKSQ VKRQEVISEL 480
LVTEAAHVRM LRVLHDLFFQ PMAECLFFPL EELQNIFPSL DELIEVHSLF LDRLMKRRQE 540
SGYLIEEIGD VLLARFDGAE GSWFQKISSR FCSRQSFALE QLKAKQRKDP RFCAFVQEAE 600
SRPRCRRLQL KDMIPTEMQR LTKYPLLLQS IGQNTEEPTE REKVELAAEC CREILHHVNQ 660
AVRDMEDLLR LKDYQRRLDL SHLRQSSDPM LSEFKNLDIT KKKLVHEGPL TWRVTKDKAV 720
EVHVLLLDDL LLLLQRQDER LLLKSHSRTL TPTPDGKTML RPVLRLTSAM TREVATDHKA 780
FYVLFTWDQE AQIYELVAQT VSERKNWCAL ITETAGSLKV PAPASRPKPR PSPSSTREPL 840
LSSSENGNGG RETSPADART ERILSDLLPF CRPGPEGQLA ATALRKVLSL KQLLFPAEED 900
NGAGPPRDGD GVPGGGPLSP ARTQEIQENL LSLEETMKQL EELEEEFCRL RPLLSQLGGN 960
SVPQPGCT 968 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR015212; Regulat_G_prot_signal-like.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR015721; RhoGEF-like. 
Pfam
 PF09128; RGS-like
 PF00621; RhoGEF 
SMART
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN 
PRINTS