CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003879
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70 kDa protein cognate 4 
Protein Synonyms/Alias
 Heat shock 70 kDa protein 88E 
Gene Name
 Hsc70-4 
Gene Synonyms/Alias
 Hsc4; CG4264 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
88AAVQSDMKHWPFEVVacetylation[1]
108PKIEVTYKDEKKTFFacetylation[1]
111EVTYKDEKKTFFPEEacetylation[1]
246THFVQEFKRKHKKDLacetylation[1]
319STMDPVEKALRDAKLacetylation[1]
524RMVNEAEKYRNEDEKacetylation[1]
559TLDEDNLKTKISDSDacetylation[1]
589DANQLADKEEYEHRQacetylation[1]
597EEYEHRQKELEGVCNacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
 CARBOHYD 35 35 N-linked (GlcNAc...).  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Nucleotide-binding; Nucleus; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 651 AA 
Protein Sequence
MSKAPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 60
MNPTQTIFDA KRLIGRKFDD AAVQSDMKHW PFEVVSADGK PKIEVTYKDE KKTFFPEEIS 120
SMVLTKMKET AEAYLGKTVT NAVITVPAYF NDSQRQATKD AGTIAGLNVL RIINEPTAAA 180
IAYGLDKKAV GERNVLIFDL GGGTFDVSIL SIDDGIFEVK STAGDTHLGG EDFDNRLVTH 240
FVQEFKRKHK KDLTTNKRAL RRLRTACERA KRTLSSSTQA SIEIDSLFEG TDFYTSITRA 300
RFEELNADLF RSTMDPVEKA LRDAKLDKSV IHDIVLVGGS TRIPKVQRLL QDLFNGKELN 360
KSINPDEAVA YGAAVQAAIL HGDKSQEVQD LLLLDVTPLS LGIETAGGVM SVLIKRNTTI 420
PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LSGIPPAPRG VPQIEVTFDI 480
DANGILNVTA LERSTNKENK ITITNDKGRL SKEDIERMVN EAEKYRNEDE KQKETIAAKN 540
GLESYCFNMK ATLDEDNLKT KISDSDRTTI LDKCNETIKW LDANQLADKE EYEHRQKELE 600
GVCNPIITKL YQGAGFPPGG MPGGPGGMPG AAGAAGAAGA GGAGPTIEEV D 651 
Gene Ontology
 GO:0071013; C:catalytic step 2 spliceosome; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005726; C:perichromatin fibrils; IDA:FlyBase.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0071011; C:precatalytic spliceosome; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0051087; F:chaperone binding; IDA:FlyBase.
 GO:0007411; P:axon guidance; IMP:FlyBase.
 GO:0007413; P:axonal fasciculation; IMP:FlyBase.
 GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:FlyBase.
 GO:0000398; P:mRNA splicing, via spliceosome; IC:FlyBase.
 GO:0007269; P:neurotransmitter secretion; IMP:FlyBase.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW.
 GO:0016246; P:RNA interference; IMP:FlyBase.
 GO:0016192; P:vesicle-mediated transport; IMP:FlyBase. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.