CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013203
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poly [ADP-ribose] polymerase 15 
Protein Synonyms/Alias
 PARP-15; ADP-ribosyltransferase diphtheria toxin-like 7; ARTD7; B-aggressive lymphoma protein 3 
Gene Name
 PARP15 
Gene Synonyms/Alias
 BAL3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106LSRAFLQKAGPMLQKubiquitination[1]
113KAGPMLQKELDDRRRubiquitination[1]
616GLVTPPPKNPHNPTDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcriptional repressor. Has ADP-ribosyltransferase activity. 
Sequence Annotation
 DOMAIN 56 245 Macro 1.
 DOMAIN 271 442 Macro 2.
 DOMAIN 460 656 PARP catalytic.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Glycosyltransferase; NAD; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 656 AA 
Protein Sequence
MHGVAGVTSR AGRDREAGSM LPAGNRGARK ASRRSSSRSM SRDNKFSKKD CLSIRNVVAS 60
IQTKEGLNLK LISGDVLYIW ADVIVNSVPM NLQLGGGPLS RAFLQKAGPM LQKELDDRRR 120
ETEEKVGNIF MTSGCNLDCK AVLHAVAPYW NNGAETSWQI MANIIKKCLT TVEVLSFSSI 180
TFPMIGTGSL QFPKAVFAKL ILSEVFEYSS STRPITSPLQ EVHFLVYTND DEGCQAFLDE 240
FTNWSRINPN KARIPMAGDT QGVVGTVSKP CFTAYEMKIG AITFQVATGD IATEQVDVIV 300
NSTARTFNRK SGVSRAILEG AGQAVESECA VLAAQPHRDF IITPGGCLKC KIIIHVPGGK 360
DVRKTVTSVL EECEQRKYTS VSLPAIGTGN AGKNPITVAD NIIDAIVDFS SQHSTPSLKT 420
VKVVIFQPEL LNIFYDSMKK RDLSASLNFQ STFSMTTCNL PEHWTDMNHQ LFCMVQLEPG 480
QSEYNTIKDK FTRTCSSYAI EKIERIQNAF LWQSYQVKKR QMDIKNDHKN NERLLFHGTD 540
ADSVPYVNQH GFNRSCAGKN AVSYGKGTYF AVDASYSAKD TYSKPDSNGR KHMYVVRVLT 600
GVFTKGRAGL VTPPPKNPHN PTDLFDSVTN NTRSPKLFVV FFDNQAYPEY LITFTA 656 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002589; A1pp.
 IPR012317; Poly(ADP-ribose)pol_cat_dom. 
Pfam
 PF01661; Macro
 PF00644; PARP 
SMART
 SM00506; A1pp 
PROSITE
 PS51154; MACRO
 PS51059; PARP_CATALYTIC 
PRINTS