CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026106
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dimethylglycine dehydrogenase 
Protein Synonyms/Alias
 Dimethylglycine dehydrogenase, mitochondrial 
Gene Name
 Dmgdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
107KIHYDSIKLYERLEEacetylation[1]
141PERVDEFKYQMTRTNacetylation[1]
161QYIIEPEKIHELFPLacetylation[1]
201ALATGARKYGALLKYacetylation[1]
216PAPVTSLKPRPDGTWacetylation[1]
250FWAREVGKMIGLDHPacetylation[1]
275TSTIPEVKALKRELPacetylation[1]
278IPEVKALKRELPVLRacetylation[1]
469QRVSGLYKILESKCSacetylation[1]
516EPVGSEYKQVMQRVGacetylation[1]
648DLSDDVFKFLQTKSLacetylation[1]
656FLQTKSLKISDIPVTacetylation[1]
754FTGKQALKQIKAKGLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 857 AA 
Protein Sequence
MLRLGALRLR GLALRSSQGR PSSAGLREGQ ESPPSPPEWK DRAETVIIGG GCVGVSLAYH 60
LAKAGMRDVV LLEKSELTAG STWHAAGLTT YFHPGINLKK IHYDSIKLYE RLEEETGQVV 120
GFHQPGSIRL ATTPERVDEF KYQMTRTNWH ATEQYIIEPE KIHELFPLLN MDKILAGLYN 180
PGDGHIDPYS LTMALATGAR KYGALLKYPA PVTSLKPRPD GTWDVETPQG SVRANRIVNA 240
AGFWAREVGK MIGLDHPLIP VQHQYVITST IPEVKALKRE LPVLRDLEGS YYLRQERDGL 300
LFGPYESQEK MKLQASWVAH GVPPGFGKEL FESDLDRITE HVEAAMEMVP VLKKADIINI 360
VNGPITYSPD ILPMVGPHQG VRNYWVAIGF GYGIIHAGGV GTYLSDWILH GEPPFDLIEL 420
DPNRYGKWTT TQYTEAKARE SYGFNNIVGY PKEERFAGRP TQRVSGLYKI LESKCSMGFH 480
AGWEQPHWFY KPGQDTQYRP SFRRTNWFEP VGSEYKQVMQ RVGVIDLSPF GKFNIKGQDS 540
TQLLDHLCAN VIPKVGFTNI SHMLTPRGRV YAELTVSHQS PGEFLLITGS GSELHDLRWI 600
EEAAVRGGYD VEIRNITDEL GVLGVAGPYA RRVLQKLTSE DLSDDVFKFL QTKSLKISDI 660
PVTAIRISYT GELGWELYHR REDSAALYER IMNAGQEEGI DNFGTYALNA LRLEKAFRAW 720
GSEMNCDTNP LEAGLDYFIK LNKPANFTGK QALKQIKAKG LKRRLVCLTL ATDNVDPEGN 780
ESVWYKGKVI GNTTSGSYSY SIQKSLAFAY VPVELSEVGQ QVEVELLGKN YPATIIQEPL 840
VLTEPTRTRL QKDGRKS 857 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0047865; F:dimethylglycine dehydrogenase activity; IEA:Compara.
 GO:0006546; P:glycine catabolic process; IEA:InterPro. 
Interpro
 IPR006076; FAD-dep_OxRdtase.
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR027266; TrmE/GcvT_dom1. 
Pfam
 PF01266; DAO
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS