CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013205
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poly [ADP-ribose] polymerase 14 
Protein Synonyms/Alias
 PARP-14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2 
Gene Name
 PARP14 
Gene Synonyms/Alias
 BAL2; KIAA1268 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
380ESTTQKIKREEQSLKubiquitination[1]
747NASNEDLKHYGGLAAubiquitination[1]
1122SDKIPKAKDTQGFYGubiquitination[1]
1276AIEDFVQKGSAQSVKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
 Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity. 
Sequence Annotation
 DOMAIN 791 978 Macro 1.
 DOMAIN 1003 1190 Macro 2.
 DOMAIN 1216 1387 Macro 3.
 DOMAIN 1523 1601 WWE.
 DOMAIN 1605 1801 PARP catalytic.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Glycosyltransferase; NAD; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1801 AA 
Protein Sequence
MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 60
EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDT 120
IRFVDDCTKH HSIKQLQLSP RLLEVTNTIR VENLPPGADD YSLKLFFENP YNGGGRVANV 180
EYFPEESSAL IEFFDRKVLD TIMATKLDFN KMPLSVFPYY ASLGTALYGK EKPLIKLPAP 240
FEESLDLPLW KFLQKKNHLI EEINDEMRRC HCELTWSQLS GKVTIRPAAT LVNEGRPRIK 300
TWQADTSTTL SSIRSKYKVN PIKVDPTMWD TIKNDVKDDR ILIEFDTLKE MVILAGKSED 360
VQSIEVQVRE LIESTTQKIK REEQSLKEKM IISPGRYFLL CHSSLLDHLL TECPEIEICY 420
DRVTQHLCLK GPSADVYKAK CEIQEKVYTM AQKNIQVSPE IFQFLQQVNW KEFSKCLFIA 480
QKILALYELE GTTVLLTSCS SEALLEAEKQ MLSALNYKRI EVENKEVLHG KKWKGLTHNL 540
LKKQNSSPNT VIINELTSET TAEVIITGCV KEVNETYKLL FNFVEQNMKI ERLVEVKPSL 600
VIDYLKTEKK LFWPKIKKVN VQVSFNPENK QKGILLTGSK TEVLKAVDIV KQVWDSVCVK 660
SVHTDKPGAK QFFQDKARFY QSEIKRLFGC YIELQENEVM KEGGSPAGQK CFSRTVLAPG 720
VVLIVQQGDL ARLPVDVVVN ASNEDLKHYG GLAAALSKAA GPELQADCDQ IVKREGRLLP 780
GNATISKAGK LPYHHVIHAV GPRWSGYEAP RCVYLLRRAV QLSLCLAEKY KYRSIAIPAI 840
SSGVFGFPLG RCVETIVSAI KENFQFKKDG HCLKEIYLVD VSEKTVEAFA EAVKTVFKAT 900
LPDTAAPPGL PPAAAGPGKT SWEKGSLVSP GGLQMLLVKE GVQNAKTDVV VNSVPLDLVL 960
SRGPLSKSLL EKAGPELQEE LDTVGQGVAV SMGTVLKTSS WNLDCRYVLH VVAPEWRNGS 1020
TSSLKIMEDI IRECMEITES LSLKSIAFPA IGTGNLGFPK NIFAELIISE VFKFSSKNQL 1080
KTLQEVHFLL HPSDHENIQA FSDEFARRAN GNLVSDKIPK AKDTQGFYGT VSSPDSGVYE 1140
MKIGSIIFQV ASGDITKEEA DVIVNSTSNS FNLKAGVSKA ILECAGQNVE RECSQQAQQR 1200
KNDYIITGGG FLRCKNIIHV IGGNDVKSSV SSVLQECEKK NYSSICLPAI GTGNAKQHPD 1260
KVAEAIIDAI EDFVQKGSAQ SVKKVKVVIF LPQVLDVFYA NMKKREGTQL SSQQSVMSKL 1320
ASFLGFSKQS PQKKNHLVLE KKTESATFRV CGENVTCVEY AISWLQDLIE KEQCPYTSED 1380
ECIKDFDEKE YQELNELQKK LNINISLDHK RPLIKVLGIS RDVMQARDEI EAMIKRVRLA 1440
KEQESRADCI SEFIEWQYND NNTSHCFNKM TNLKLEDARR EKKKTVDVKI NHRHYTVNLN 1500
TYTATDTKGH SLSVQRLTKS KVDIPAHWSD MKQQNFCVVE LLPSDPEYNT VASKFNQTCS 1560
HFRIEKIERI QNPDLWNSYQ AKKKTMDAKN GQTMNEKQLF HGTDAGSVPH VNRNGFNRSY 1620
AGKNAVAYGK GTYFAVNANY SANDTYSRPD ANGRKHVYYV RVLTGIYTHG NHSLIVPPSK 1680
NPQNPTDLYD TVTDNVHHPS LFVAFYDYQA YPEYLITFRK 1720 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR002589; A1pp.
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004170; WWE-dom. 
Pfam
 PF01661; Macro
 PF00644; PARP
 PF02825; WWE 
SMART
 SM00506; A1pp 
PROSITE
 PS51154; MACRO
 PS51059; PARP_CATALYTIC
 PS50918; WWE 
PRINTS