Tag | Content |
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CPLM ID | CPLM-013205 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Poly [ADP-ribose] polymerase 14 |
Protein Synonyms/Alias | PARP-14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2 |
Gene Name | PARP14 |
Gene Synonyms/Alias | BAL2; KIAA1268 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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380 | ESTTQKIKREEQSLK | ubiquitination | [1] | 747 | NASNEDLKHYGGLAA | ubiquitination | [1] | 1122 | SDKIPKAKDTQGFYG | ubiquitination | [1] | 1276 | AIEDFVQKGSAQSVK | ubiquitination | [1] |
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Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity. |
Sequence Annotation | DOMAIN 791 978 Macro 1. DOMAIN 1003 1190 Macro 2. DOMAIN 1216 1387 Macro 3. DOMAIN 1523 1601 WWE. DOMAIN 1605 1801 PARP catalytic. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Glycosyltransferase; NAD; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1801 AA |
Protein Sequence | MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 60 EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDT 120 IRFVDDCTKH HSIKQLQLSP RLLEVTNTIR VENLPPGADD YSLKLFFENP YNGGGRVANV 180 EYFPEESSAL IEFFDRKVLD TIMATKLDFN KMPLSVFPYY ASLGTALYGK EKPLIKLPAP 240 FEESLDLPLW KFLQKKNHLI EEINDEMRRC HCELTWSQLS GKVTIRPAAT LVNEGRPRIK 300 TWQADTSTTL SSIRSKYKVN PIKVDPTMWD TIKNDVKDDR ILIEFDTLKE MVILAGKSED 360 VQSIEVQVRE LIESTTQKIK REEQSLKEKM IISPGRYFLL CHSSLLDHLL TECPEIEICY 420 DRVTQHLCLK GPSADVYKAK CEIQEKVYTM AQKNIQVSPE IFQFLQQVNW KEFSKCLFIA 480 QKILALYELE GTTVLLTSCS SEALLEAEKQ MLSALNYKRI EVENKEVLHG KKWKGLTHNL 540 LKKQNSSPNT VIINELTSET TAEVIITGCV KEVNETYKLL FNFVEQNMKI ERLVEVKPSL 600 VIDYLKTEKK LFWPKIKKVN VQVSFNPENK QKGILLTGSK TEVLKAVDIV KQVWDSVCVK 660 SVHTDKPGAK QFFQDKARFY QSEIKRLFGC YIELQENEVM KEGGSPAGQK CFSRTVLAPG 720 VVLIVQQGDL ARLPVDVVVN ASNEDLKHYG GLAAALSKAA GPELQADCDQ IVKREGRLLP 780 GNATISKAGK LPYHHVIHAV GPRWSGYEAP RCVYLLRRAV QLSLCLAEKY KYRSIAIPAI 840 SSGVFGFPLG RCVETIVSAI KENFQFKKDG HCLKEIYLVD VSEKTVEAFA EAVKTVFKAT 900 LPDTAAPPGL PPAAAGPGKT SWEKGSLVSP GGLQMLLVKE GVQNAKTDVV VNSVPLDLVL 960 SRGPLSKSLL EKAGPELQEE LDTVGQGVAV SMGTVLKTSS WNLDCRYVLH VVAPEWRNGS 1020 TSSLKIMEDI IRECMEITES LSLKSIAFPA IGTGNLGFPK NIFAELIISE VFKFSSKNQL 1080 KTLQEVHFLL HPSDHENIQA FSDEFARRAN GNLVSDKIPK AKDTQGFYGT VSSPDSGVYE 1140 MKIGSIIFQV ASGDITKEEA DVIVNSTSNS FNLKAGVSKA ILECAGQNVE RECSQQAQQR 1200 KNDYIITGGG FLRCKNIIHV IGGNDVKSSV SSVLQECEKK NYSSICLPAI GTGNAKQHPD 1260 KVAEAIIDAI EDFVQKGSAQ SVKKVKVVIF LPQVLDVFYA NMKKREGTQL SSQQSVMSKL 1320 ASFLGFSKQS PQKKNHLVLE KKTESATFRV CGENVTCVEY AISWLQDLIE KEQCPYTSED 1380 ECIKDFDEKE YQELNELQKK LNINISLDHK RPLIKVLGIS RDVMQARDEI EAMIKRVRLA 1440 KEQESRADCI SEFIEWQYND NNTSHCFNKM TNLKLEDARR EKKKTVDVKI NHRHYTVNLN 1500 TYTATDTKGH SLSVQRLTKS KVDIPAHWSD MKQQNFCVVE LLPSDPEYNT VASKFNQTCS 1560 HFRIEKIERI QNPDLWNSYQ AKKKTMDAKN GQTMNEKQLF HGTDAGSVPH VNRNGFNRSY 1620 AGKNAVAYGK GTYFAVNANY SANDTYSRPD ANGRKHVYYV RVLTGIYTHG NHSLIVPPSK 1680 NPQNPTDLYD TVTDNVHHPS LFVAFYDYQA YPEYLITFRK 1720 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:HPA. GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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