| Tag | Content |
|---|
| CPLM ID | CPLM-001413 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A-kinase anchor protein 10, mitochondrial |
Protein Synonyms/Alias | AKAP-10; Dual specificity A kinase-anchoring protein 2; D-AKAP-2; Protein kinase A-anchoring protein 10; PRKA10 |
Gene Name | Akap10 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 621 | MFSQAMKKWVQGNTD | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase. |
Sequence Annotation | DOMAIN 125 369 RGS 1.
DOMAIN 379 505 RGS 2.
REGION 634 647 PKA-RII subunit binding.
MOD_RES 52 52 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Repeat; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 662 AA |
Protein Sequence | MRGAGPSPRH SPRALRPDPG PAMSFFRRKV KGKEQEKTLD VKSTKASVAV HSPQKSTKNH 60
ALLEAAGPSH VAINAISANM DSFSSSRTAT LKKQPSHMEA AHFGDLGRSC LDYQTQETKS 120
SLSKTLEQVL RDTVVLPYFL QFMELRRMEH LVKFWLEAES FHSTTWSRIR AHSLNTVKQS 180
SLAEPVSPSK RHETPASSVT EALDRRLGDS SSAPLLVTQS EGTDLSSRTQ NPQNHLLLSQ 240
EGHSARSLHR EVARTGSHQI PTDSQDSSSR LAVGSRNSCS SPLRELSEKL MKSIEQDAVN 300
TFTKYISPDA AKPIPITEAM RNDIIAKICG EDGQVDPNCF VLAQAVVFSA MEQEHFSEFL 360
RSHHFCKYQI EVLTSGTVYL ADILFCESAL FYFSEYMEKE DAVNILQFWL AADNFQSQLA 420
AKKGQYDGQE AQNDAMILYD KYFSLQATHP LGFDDVVRLE IESNICREGG PLPNCFTTPL 480
RQAWTTMEKV FLPGFLSSNL YYKYLNDLIH SVRGDEFLGG NVSLAAHGSV CLPEESHSGG 540
SDGSTAQSSV KKASIKILKN FDEAIIVDAA SLDPESLYQR TYAGKMSFGR VSDLGQFIRE 600
SEPEPDVKKS KGFMFSQAMK KWVQGNTDEA QEELAWKIAK MIVSDVMQQA HHDQPLEKST 660
KL 662 |
Gene Ontology | GO:0005739; C:mitochondrion; IDA:MGI. GO:0005886; C:plasma membrane; IEA:Compara. GO:0051018; F:protein kinase A binding; ISS:MGI. GO:0008104; P:protein localization; IDA:MGI. GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |